Skip to main content
SpringerLink
Log in

The protective effect of Shenfu injection against elderly severe pneumonia

  • Original Article
  • Published:
European Journal of Trauma and Emergency Surgery Aims and scope Submit manuscript

Abstract

Objective

The purpose of this study is to investigate the effect of Shenfu injection (SFI) on the tumor necrosis factor-α (TNF-α) and the interleukin (IL-6, IL-8, IL-10) of elderly patients who suffered from severe pneumonia.

Methods

From June 2012 to September 2014, we performed in our department 89 cases of elderly patients with severe pneumonia. These patients were randomly divided into two groups: the treatment group (45 cases) and the control group (44 cases). The control group was given the treatment of anti-infection, reducing sputum, and support therapy, while the treatment group was fed by SFI intravenously based on the control group. The TNF-α and the interleukin were detected by enzyme-linked immunosorbent assay (ELISA). Meanwhile, the changes in the inflammatory response indicators, the blood gas analysis, and the parameters of vital signs were measured and compared before and after therapy.

Results

Prior to treatment, there is no significant difference between the treatment group and the control group (p > 0.05); after the treatment for 7 days, the levels of TNF-α, IL-6, and IL-8 were significantly decreased, while the level of IL-10 was obviously increased. The APACHE II score was significantly decreased in comparison to that before the treatment (p < 0.05), and the time of mechanical ventilation, the duration of time in ICU, and the application time of vasoactive drugs were notably shortened.

Conclusion

The application of Shenfu injection exhibited a positive and effective effect on removing the inflammation media during the treatment of elderly severe pneumonia.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. El-Solh AA, Sikka P, Ramadan F, Davies J. Etiology of severe pneumonia in the very elderly. Am J Respir Crit Care Med. 2001;163:645–51.

    Article  CAS  PubMed  Google Scholar 

  2. Pinner RW, Teutsch SM, Simonsen L, Klug LA, Graber JM, Clarke MJ, Berkelman RL. Trends in infectious diseases mortality in the United States. JAMA. 1996;275:189–93.

    Article  CAS  PubMed  Google Scholar 

  3. Almirall J, Mesalles E, Klamburg J, Parra O, Agudo A. Prognostic factors of pneumonia requiring admission to the intensive care unit. Chest. 1995;107:511–6.

    Article  CAS  PubMed  Google Scholar 

  4. Günther A, Mosavi P, Heinemann S, Ruppert C, Muth H, Markart P, Grimminger F, Walmrath D, Temmesfeld-Wollbrück B, Seeger W. Alveolar fibrin formation caused by enhanced procoagulant and depressed fibrinolytic capacities in severe pneumonia. Am J Respir Crit Care Med. 2000;161:454–62.

    Article  PubMed  Google Scholar 

  5. Bauer TT, Montón C, Torres A, Cabello H, Fillela X, Maldonado A, Nicolás JM, Zavala E. Comparison of systemic cytokine levels in patients with acute respiratory distress syndrome, severe pneumonia, and controls. Thorax. 2000;55:46–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Zhang Q, Li CS, Wang S, Gu W. Effects of Chinese medicine Shen-Fu injection on the expression of inflammatory cytokines and complements during post-resuscitation immune dysfunction in A porcine model. Chin J Integr Med. 2016;22:101–9.

    Article  PubMed  Google Scholar 

  7. Wang J, Qiao LF, Yang GT. Role of Shenfu injection in rats with systemic inflammatory response syndrome. Chin J Integr Med. 2008;14:51–5.

    Article  PubMed  Google Scholar 

  8. Mandell LA, Wunderink RG, Anzueto A, Bartlett JG, Campbell GD, Dean NC, Dowell SF, File TM, Musher DM, Niederman MS, Torres A, Whitney CG. Infectious Diseases Society of America/American Thoracic Society consensus guidelines on the management of community-acquired pneumonia in adults. Clin Infect Dis. 2007;44:27–72.

    Article  Google Scholar 

  9. Guo KP, Liu YN, Li K. Adult severe community acquired pneumonia of inflammatory factors in blood serum and its clinical significance. Guide China Med. 2012;10:420–2.

    Google Scholar 

  10. Tang ZX, Zeng M, Lu GF. Changes of plasma levels of soluble triggering receptor expressed on myeloid cell-1, tumor necrosis factor-α and interleukin-10 in severe pneumonia. Chin J Respir Crit Care Med. 2011;10:424–8.

    CAS  Google Scholar 

  11. Sun L, Comell TT, Le Vine A, Berlin AA, Hinkovska-Galcheva V, Fleszar AJ, Lukacs NW, Shanley TP. Dual role of interleukin-10 in the regulation of respiratory syncitial virus (RSV)-induced lung inflammation. Clin Exp Immunol. 2013;172:263–79.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  12. Hou XM, Li CS, Gu W, Guo ZJ, Yin WP, Zhang D. Effect of Shenfu on inflammatory cytokine release and brain edema after prolonged cardiac arrest in the swine. Am J Emerg Med. 2013;31:1159–64.

    Article  PubMed  Google Scholar 

  13. Lin H, Ma C, Wang R, Liang D. Effect of Shenfu injection on blood lactate and prognosis in patients with severe pneumonia. J Emerg Tradit Chin Med. 2013;22:199–200.

    Google Scholar 

  14. Li P. Hemodynamic effects of severe pneumonia by Shenfu injection. Guide China Med. 2012;10:52–3.

    Google Scholar 

  15. Li G, Zhao JF, Wang KC, Chen HP. Impact of Shenfu injection on neuroendocrine-immune network in experimental septic rats. Chin J Surg Integr Tradit West Med. 2011;17:185–9.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Emergency, Hangzhou Normal University Affiliated Hospital, Wenzhou Road 126, Hangzhou, 310015, Zhejiang, People’s Republic of China

    S. J. Lv, D. P. Lai, X. Wei, Q. Yan & J. M. Xia

Authors
  1. S. J. Lv
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. D. P. Lai
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. X. Wei
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Q. Yan
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. J. M. Xia
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to S. J. Lv.

Ethics declarations

The authors state that the effect that all human and animal studies have been approved by the appropriate ethics committee and have, therefore, been performed in accordance with the ethical standards laid down in the 1964 Declaration of Helsinki and its later amendments.

Conflict of interest

Shi-Jin Lv, Deng-Pan Lai, Xia Wei, Qian Yan, and Jin-Ming Xia declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Lv, S.J., Lai, D.P., Wei, X. et al. The protective effect of Shenfu injection against elderly severe pneumonia. Eur J Trauma Emerg Surg 43, 711–715 (2017). https://doi.org/10.1007/s00068-016-0713-2

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00068-016-0713-2

Keywords

Search

Navigation