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Prediction of immediate and long-term benefit after kyphoplasty of painful osteoporotic vertebral fractures by preoperative MRI

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European Journal of Trauma and Emergency Surgery Aims and scope Submit manuscript

Abstract

Background

It is unclear if an MR-detectable bone marrow edema is a prerequisite for pain reduction and morphological correction by kyphoplasty. This comparative trial evaluates clinical and radiomorphological outcomes after kyphoplasty of painful osteoporotic vertebral fractures with and without preoperative MR-detectable bone marrow edema for 1 year of follow-up.

Methods

Preoperative MR-images of 45 patients who received kyphoplasty for treatment of painful osteoporotic vertebral fractures were evaluated with regard to presence (n = 27) or absence (n = 18) of vertebral bone marrow edema. Pain scores (VAS 0-100) and radiomorphological measures (midline vertebral height, kyphosis angle) were analysed at baseline, postoperatively and after 12 months.

Results

In the “bone edema” group, pain scores improved from 72.7 to 46.8 (postoperative) and 48.0 (12 months, P < 0.001, both). In the group without preoperative bone edema, pain score improved from 70.7 to 60.3 (postoperative, P = 0.013) and to 50.1 (12 months, P = 0.001). Pain scores of both groups were significantly different directly postoperative (P = 0.026), but not after 12 months (P = 0.714). Vertebral height restoration was slightly greater in the “bone edema” group (10.2% vs. 7.8%, P = 0.289). Correction of the kyphosis angle was greater in the “bone edema” group (P = 0.014) compared to the “no bone edema” group (P = 0.838).

Conclusion

A preoperative MR-detectable vertebral bone marrow edema predicts a better short-term outcome after kyphoplasty, but is not a prerequisite for long-term pain reduction in patients with old, chronically painful osteoporotic vertebral fractures.

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Acknowledgments

This work was supported by the Havemann family and the Dietmar Hopp foundation. Dres. Meeder and Kasperk received honoraria for lectures from Medtronic.

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None.

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Authors and Affiliations

  1. Division of Osteology, Department of Medicine I and Clinical Chemistry, Ruprecht-Karls-University of Heidelberg, Im Neuenheimer Feld 410, 69120, Heidelberg, Germany

    I. A. Grafe, P. Nawroth & C. Kasperk

  2. Department of Radiology, University of Heidelberg, INF 410, 69120, Heidelberg, Germany

    G. Nöldge & M. Libicher

  3. Department of Biostatistics, Faculty of Clinical Medicine Mannheim, University of Heidelberg, INF 410, 69120, Heidelberg, Germany

    C. Weiss

  4. Department of Orthopedic Surgery, University of Heidelberg, INF 410, 69120, Heidelberg, Germany

    M. Baier, P.-J. Meeder & B. Wiedenhöfer

Authors
  1. I. A. Grafe
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  2. G. Nöldge
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  3. C. Weiss
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  4. M. Libicher
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  5. M. Baier
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  6. P. Nawroth
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  7. P.-J. Meeder
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  8. B. Wiedenhöfer
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  9. C. Kasperk
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Corresponding author

Correspondence to C. Kasperk.

Additional information

I. A. Grafe and G. Nöldge contributed equally to this work.

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Grafe, I.A., Nöldge, G., Weiss, C. et al. Prediction of immediate and long-term benefit after kyphoplasty of painful osteoporotic vertebral fractures by preoperative MRI. Eur J Trauma Emerg Surg 37, 379–386 (2011). https://doi.org/10.1007/s00068-010-0050-9

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  • DOI: https://doi.org/10.1007/s00068-010-0050-9

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