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Capacitabine und Oxaliplatin (XelOx) im Vergleich zu Fluorouracil/Folinsäure als adjuvante Therapie bei Kolonkarzinomen im Stadium III: Ergebnisse der kontrollierten randomisierten Phase III-Studie NO16968

Capecitabine Plus Oxaliplatin Compared With Fluorouracil/Folinic Acid As Adjuvant Therapy for Stage III Colon Cancer: Final Results of the NO16968 Randomized Controlled Phase III Trial

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Literatur

  1. André T, Boni C, Navarro M, Tabernero J, Hickish T, Topham C, Bonetti A, Clingan P, Bridgewater J, Rivera F, Gramont A de (2009) Improved overall survival with oxaliplatin, fluorouracil, and leucovorin as adjuvant treatment in stage II or III colon cancer in the MOSAIC trial. J Clin Oncol 27(19):3109–3116. doi:10.1200/JCO.2008.20.6771

    Article  PubMed  Google Scholar 

  2. Yothers G, O’Connell MJ, Allegra CJ, Kuebler JP, Colangelo LH, Petrelli NJ, Wolmark N (2011) Oxaliplatin as adjuvant therapy for colon cancer: updated results of NSABP C‑07 trial, including survival and subset analyses. J Clin Oncol 29(28):3768–3774. doi:10.1200/JCO.2011.36.4539

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Haller DG, Tabernero J, Maroun J, Braud F de, Price T, Van Cutsem E, Hill M, Gilberg F, Rittweger K, Schmoll HJ (2011) Capecitabine plus oxaliplatin compared with fluorouracil and folinic acid as adjuvant therapy for stage III colon cancer. J Clin Oncol 29(11):1465–1471 (Epub 2011 Mar 7) doi:10.1200/JCO.2010.33.6297.

    Article  CAS  PubMed  Google Scholar 

  4. Schmoll HJ, Tabernero J, Maroun J, Braud F de, Price T, Van Cutsem E, Hill M, Hoersch S, Rittweger K, Haller DG (2015) Capecitabine plus Oxaliplatin compared with Fluorouracil/Folinic acid as adjuvant therapy for stage III colon cancer: final results of the NO16968 Randomized Controlled Phase III Trial. J Clin Oncol 33(32):3733–3740 (Epub 2015 Aug 31) doi:10.1200/JCO.2015.60.9107.

    Article  CAS  PubMed  Google Scholar 

  5. Schmoll HJ, Cartwright T, Tabernero J, Nowacki MP, Figer A, Maroun J, Price T, Lim R, Van Cutsem E, Park YS, McKendrick J, Topham C, Soler-Gonzalez G, Braud F de, Hill M, Sirzén F, Haller DG (2007) Phase III trial of capecitabine plus oxaliplatin as adjuvant therapy for stage III colon cancer: a planned safety analysis in 1,864 patients. J Clin Oncol 25(1):102–109

    Article  CAS  PubMed  Google Scholar 

  6. Haller DG, O’Connell MJ, Cartwright TH, Twelves CJ, McKenna EF, Sun W, Saif MW, Lee S, Yothers G, Schmoll HJ (2015) Impact of age and medical comorbidity on adjuvant treatment outcomes for stage III colon cancer: a pooled analysis of individual patient data from four randomized, controlled trials. Ann Oncol 26(4):715–724 (Epub 2015 Jan 16) doi:10.1093/annonc/mdv003.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

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Correspondence to Stefan Kubicka.

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S. Kubicka gibt an, Honorare von Roche, Amgen, Sanofi-Aventis, Bayer und Baxalta für Advisory-Board-Meetings, wissenschaftliche Vorträge sowie für Kongressreisen erhalten zu haben.

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Originalpublikation Schmoll HJ, Tabernero J, Maroun J et al (2015) Capecitabine plus Oxaliplatin compared with Fluorouracil/Folinic Acid as adjuvant therapy for stage III colon cancer: Final results of the NO16968 randomized controlled phase III trial. J Clin Oncol 33(32):3733–40. doi: 10.1200/JCO.2015.60.9107. Epub 2015 Aug 31

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Kubicka, S. Capacitabine und Oxaliplatin (XelOx) im Vergleich zu Fluorouracil/Folinsäure als adjuvante Therapie bei Kolonkarzinomen im Stadium III: Ergebnisse der kontrollierten randomisierten Phase III-Studie NO16968. Strahlenther Onkol 192, 505–506 (2016). https://doi.org/10.1007/s00066-016-0991-y

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