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Dos and Don’ts für Kristalloide in der Intensivmedizin

Kann zu viel Wasser schlecht sein?

Dos and don’ts for crystalloids in intensive care medicine

Can too much water be bad?

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Medizinische Klinik - Intensivmedizin und Notfallmedizin Aims and scope Submit manuscript

Zusammenfassung

Ungeachtet der Verwendung von Kolloiden haben Kristalloide in der heutigen Intensivmedizin einen festen Stellenwert: Neben der Substitution als Basisbedarf des Organismus oder Medikamententräger werden sie primär zum Volumenersatz verwendet. Eine häufige Komplikation ist die Entwicklung von interstitiellen Ödemen, was in der Zusammensetzung dieser Lösungen und der Permeabilität der Glykokalyx liegt.

Bei der Vielzahl auf dem Markt befindlicher Varianten haben sich mittlerweile die auf Bikarbonatvorläufer basierenden isotonen balancierten Vollelektrolytlösungen herauskristallisiert. Die Verwendung von 0,9 %iger Kochsalzlösung ist inzwischen als obsolet anzusehen.

Bei niedrigen Anschaffungskosten und gutem Sicherheitsprofil sind in der Anwendung von Kristalloiden wenige relevante Dinge, wie die Gefahr der Hypervolämie und Dysbalance des Elektrolythaushalts, zu beachten.

Abstract

Notwithstanding the use of colloids, crystalloids have a firm position in todayʼs intensive care: In addition to the substitution as a basic requirement of the human organism or drug carriers, they are primarily used for volume replacement. A common complication is the development of interstitial edema, which is due to the composition of these solutions and the permeability of the glycocalyx.

With the large variety available on the market, bicarbonate-based precursor isotonic-balanced full electrolyte solutions have become established in the meantime. The use of 0.9 % saline solution is regarded as obsolete.

With low cost and a good safety profile, a few relevant aspects, e.g., the risk of hypervolemia and electrolyte imbalance, must be taken into account in the use of crystalloids.

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Literatur

  1. Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M, Early Goal-Directed Therapy Collaborative Group (2001) Early goal-directed therapy in the treatment of severe sepsis and septic shock. N Engl J Med 345(19):1368–1377

    Article  CAS  PubMed  Google Scholar 

  2. Latta T (1831/1832) Letter from Dr Latta to the Secretary of the Central Board of Health, London, affording a view of the rationale and results of his practice in the treatment of cholera by aqueous and saline injections. Lancet 2:274–277

    Google Scholar 

  3. Stoneham MD, Hill EL (1997) Variability in post-operative fluid and electrolyte prescription. Br J Clin Pract 51(2):82–84

    CAS  PubMed  Google Scholar 

  4. Brandstrup B, Tønnesen H, Beier-Holgersen R, Hjortsø E, Ørding H, Lindorff-Larsen K, Rasmussen MS, Lanng C, Wallin L, Iversen LH, Gramkow CS, Okholm M, Blemmer T, Svendsen PE, Rottensten HH, Thage B, Riis J, Jeppesen IS, Teilum D, Christensen AM, Graungaard B, Pott F, Danish Study Group on Perioperative Fluid Therapy (2003) Effects of intravenous fluid restriction on postoperative complications: comparison of two perioperative fluid regimens: a randomized assessor-blinded multicenter trial. Ann Surg 238(5):641–648

    Article  PubMed Central  PubMed  Google Scholar 

  5. Baumber CD, Clark RG (1974) Insensible water loss in surgical patients. Br J Surg 61(1):53–56

    Article  CAS  PubMed  Google Scholar 

  6. Lamke LO, Nilsson GE, Reithner HL (1997) Water loss by evaporation from the abdominal cavity during surgery. Acta Chir Scand 143(5):279–284

    Google Scholar 

  7. Lobo DN, Stanga Z, Aloysius MM, Wicks C, Nunes QM, Ingram KL, Risch L, Allison SP (2010) Effect of volume loading with 1 liter intravenous infusions of 0.9 % saline, 4 % succinylated gelatine (Gelofusine) and 6 % hydroxyethyl starch (Voluven) on blood volume and endocrine responses: a randomized, three-way crossover study in healthy volunteers. Crit Care Med 38(2):464–470. doi:10.1097/CCM.0b013e3181bc80f1

    Article  CAS  PubMed  Google Scholar 

  8. Jacob M, Chappell D, Hofmann-Kiefer K, Helfen T, Schuelke A, Jacob B, Burges A, Conzen P, Rehm M (2012) The intravascular volume effect of Ringer’s lactate is below 20 %: a prospective study in humans. Crit Care 16(3):R86. doi:10.1186/cc11344

    Article  PubMed Central  PubMed  Google Scholar 

  9. Ertmer C, Rehberg S, Westphal M (2011) Flüssigkeits- und Volumentherapie in der Intensivmedizin. Intensivmedizin up2date 7. doi:http://dx.doi.org/10.1055/s-0030-1256721

  10. Burdett E, Dushianthan A, Bennett-Guerrero E, Cro S, Gan TJ, Grocott MP, James MF, Mythen MG, O’Malley CM, Roche AM, Rowan K (2012) Perioperative buffered versus non-buffered fluid administration for surgery in adults. Cochrane Database Syst Rev 12:CD004089. doi:10.1002/14651858.CD004089.pub2

    PubMed  Google Scholar 

  11. Roquilly A, Loutrel O, Cinotti R, Rosenczweig E, Flet L, Mahe PJ, Dumont R, Marie Chupin A, Peneau C, Lejus C, Blanloeil Y, Volteau C, Asehnoune K (2013) Balanced versus chloride-rich solutions for fluid resuscitation in brain-injured patients: a randomised double-blind pilot study. Crit Care 17(2):R77. doi:10.1186/cc12686

    Article  PubMed Central  PubMed  Google Scholar 

  12. Yunos NM, Bellomo R, Hegarty C, Story D, Ho L, Bailey M (2012) Association between a chloride-liberal vs chloride-restrictive intravenous fluid administration strategy and kidney injury in critically ill adults. JAMA 308(15):1566–1572. doi:10.1001/jama.2012.13356

    Article  CAS  PubMed  Google Scholar 

  13. McAlister V, Burns KEA, Znajda T, Church B (2010) Hypertonic saline for peri-operative fluid management. Cochrane Database Syst Rev (1):CD005576. doi:10.1002/14651858.CD005576.pub2

  14. Khajavi MR, Etezadi F, Moharari RS, Imani F, Meysamie AP, Khashayar P, Najafi A (2008) Effects of normal saline vs. lactated ringer’s during renal transplantation. Ren Fail 30(5):535–539. doi:10.1080/08860220802064770

    Article  CAS  PubMed  Google Scholar 

  15. Reitsma S, Slaaf DW, Vink H, van Zandvoort MA, oude Egbrink MG (2007) The endothelial glycocalyx: composition, functions, and visualization. Pflugers Arch 454(3):345–359. (Epub 2007 Jan 26)

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  16. Woodcock TE, Woodcock TM (2012) Revised starling equation and the glycocalyx model of transvascular fluid exchange: an improved paradigm for prescribing intravenous fluid therapy. Br J Anaesth 108(3):384–394. doi:10.1093/bja/aer515. (Epub 2012 Jan 29)

    Article  CAS  PubMed  Google Scholar 

  17. Pries AR, Kuebler WM (2006) Normal endothelium. Handb Exp Pharmacol 176(Pt 1):1–40

  18. Chappell D, Westphal M, Jacob M (2009) The impact of the glycocalyx on microcirculatory oxygen distribution in critical illness. Curr Opin Anaesthesiol 22(2):155–162. doi: 10.1097/ACO.0b013e328328d1b6

    Article  PubMed  Google Scholar 

  19. Bruegger D, Jacob M, Rehm M, Loetsch M, Welsch U, Conzen P, Becker BF (2005) Atrial natriuretic peptide induces shedding of endothelial glycocalyx in coronary vascular bed of guinea pig hearts. Am J Physiol Heart Circ Physiol 289(5):H1993–1999.( Epub 2005 Jun 17)

    Article  CAS  PubMed  Google Scholar 

  20. Finfer S, Bellomo R, Boyce N, French J, Myburgh J, Norton R, SAFE Study Investigators (2004) A comparison of albumin and saline for fluid resuscitation in the intensive care unit. N Engl J Med 350(22):2247–2256

    Article  CAS  PubMed  Google Scholar 

  21. ARISE Investigators, ANZICS Clinical Trials Group, Peake SL, Delaney A, Bailey M, Bellomo R, Cameron PA, Cooper DJ, Higgins AM, Holdgate A, Howe BD, Webb SA, Williams P (2014) Goal-directed resuscitation for patients with early septic shock. N Engl J Med 371(16):1496–1506. doi:10.1056/NEJMoa1404380. (Epub 2014 Oct 1)

    Article  CAS  PubMed  Google Scholar 

  22. Uhlig C, Silva PL, Deckert S, Schmitt J, de Abreu MG (2014) Albumin versus crystalloid solutions in patients with the acute respiratory distress syndrome: a systematic review and meta-analysis. Crit Care 18(1):R10. doi:10.1186/cc13187

    Article  PubMed Central  PubMed  Google Scholar 

  23. Jacob M, Saller T, Chappell D, Rehm M, Welsch U, Becker BF (2013) Physiological levels of A-, B- and C-type natriuretic peptide shed the endothelial glycocalyx and enhance vascular permeability. Basic Res Cardiol 108:347. doi:10.1007/s00395-013-0347-z

    Article  PubMed  Google Scholar 

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Correspondence to R. Wildenauer.

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R. Wildenauer gibt an, Vortragshonorare und Reisekostenerstattungen von CSL Behring GmbH erhalten zu haben und Inhaber von Aktien der Fresenius SE & Co. KGaA zu sein.

Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Wildenauer, R. Dos and Don’ts für Kristalloide in der Intensivmedizin. Med Klin Intensivmed Notfmed 110, 127–132 (2015). https://doi.org/10.1007/s00063-015-0007-1

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