Literatur
Chambers CA, Kuhns MS, Egen JG, Allison JP. CTLA-4-mediated inhibition in regulation of T cell responses: mechanisms and manipulation in tumor immunotherapy. Annu Rev Immunol 2001;19:565–594.
Waterhouse P, Penninger JM, Timms E, et al. Lymphoproliferative disorders with early lethality in mice deficient in CTLA-4. Science 1995;270:985–988.
Hodi FS, O’Day SJ, McDermott DF, et al. Improved survival with ipilimumab in patients with metastatic melanoma. N Engl J Med 2010;363:711–723.
Prieto PA, Yang JC, Sherry RM, et al. Cytotoxic T lymphocyte-associated antigen 4 blockade with ipilimumab: long-term follow-up of 179 patients with metastatic melanoma. J Clin Oncol 2010;28:Suppl:15s.
Literatur
Flaherty KT, Puzanov I, Kim KB, et al. Inhibition of mutated, activated BRAF in metastatic melanoma. N Engl J Med 2010;363:809–819.
Davies H, Bignell GR, Cox C, et al. Mutations of the BRAF gene in human cancer. Nature 2002; 417:949–954.
Hodi FS, Friedlander P, Corless CL, et al. Major response to imatinib mesylate in KIT-mutated melanoma. J Clin Oncol 2008;26:2046–2051.
Wellbrock C, Karasarides M, Marais R. The RAF proteins take centre stage. Nat Rev Mol Cell Biol 2004;5:875–885.
Poulikakos PI, Zhang C, Bollag G, Shokat KM, Rosen N. RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF. Nature 2010;464:427–430.
Literatur
Maio M, Mackiewicz A, Testori A, Trefzer U, Ferraresi V, Jassem J, et al. Large Randomized Study of Thymosin á1, Interferon Alfa, or Both in Combination With Dacarbazine in Patients With Metastatic Melanoma. J Clin Oncol 2010; 28(10):1780–1787.
Literatur
Temel JS, Greer JA, Muzikansky A, et al. Early Palliative Care for Patients with Metastatic Non-Small-Cell Lung Cancer. N Engl J Med 2010; 363:733–742.
Literatur
Bolland MJ, Avenell A, Baron JA, et al. Effect of calcium supplements on risk of myocardial infarction and cardiovascular events: meta-analysis. BMJ 2010; 341:c3691.
Rights and permissions
About this article
Cite this article
Journal Club. Med Klin 105, 936–942 (2010). https://doi.org/10.1007/s00063-010-1160-1
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00063-010-1160-1