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Therapie von Fettstoffwechselstörungen

Treatment of lipid disorders

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Zusammenfassung

Störungen des Lipidstoffwechsels spielen eine entscheidende Rolle bei der Entstehung atherosklerotisch bedingter Gefäßerkrankungen. Zentraler Bestandteil der Diagnostik ist die Einschätzung des individuellen kardiovaskulären Risikos durch gezielte Anamnese und Risiko-Scores. Aufgrund der überragenden prognostischen Bedeutung steht die Reduktion des LDL-Cholesterins mit Statinen weiterhin im Mittelpunkt der Therapie und stellt die wichtigste medikamentöse Intervention für die Primär- und Sekundärprävention atherosklerotischer Erkrankungen dar. Unverzichtbarer Bestandteil der Therapie vor allem für Patienten mit erhöhten Triglyzeridwerten sind Lebensstilmaßnahmen zur Reduktion begleitender Risikofaktoren, insbesondere körperliche Aktivität und Nikotinstop.

Abstract

Lipid disorders play an essential role in the pathogenesis of atherosclerotic diseases. An integral part of the clinical evaluation is the estimation of the individual cardiovascular risk using risk scores and patient history. Due to the long established prognostic relevance, reduction of low-density lipoproteins (LDL) using statins remains beyond doubt the central intervention both in primary and secondary prevention of atherosclerotic diseases. Indispensible components of treatment in all patients with elevated triglyceride levels are lifestyle changes contributing to a reduction of accompanying risk factors, in particular physical activity and smoking cessation.

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Einhaltung ethischer Richtlinien

Interessenkonflikt. F. Custodis und U. Laufs geben an, dass kein Interessenkonflikt besteht. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

Die Autoren erklären, dass sie sich bei der Erstellung des Beitrags von keinen wirtschaftlichen Interessen leiten ließen. Die Autoren legen folgende potenziellen Interessenkonflikte offen: keine. Der Verlag erklärt, dass die inhaltliche Qualität des Beitrags von zwei unabhängigen Gutachtern geprüft wurde. Werbung in dieser Zeitschriftenausgabe hat keinen Bezug zur CME-Fortbildung. Der Verlag garantiert, dass die CME-Fortbildung sowie die CME-Fragen frei sind von werblichen Aussagen und keinerlei Produktempfehlungen enthalten. Dies gilt insbesondere für Präparate, die zur Therapie des dargestellten Krankheitsbilds geeignet sind.

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  1. Klinik f. Innere Medizin III, Kardiologie, Angiologie und Internistische Intensivmedizin, Universitätsklinik des Saarlandes, 66421, Homburg/Saar, Deutschland

    F. Custodis & U. Laufs

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  1. F. Custodis
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  2. U. Laufs
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Correspondence to F. Custodis.

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Custodis, F., Laufs, U. Therapie von Fettstoffwechselstörungen. Herz 39, 119–130 (2014). https://doi.org/10.1007/s00059-013-4013-x

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