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Synthesis, characterization and in vitro antimicrobial evaluation of some novel hydrazone derivatives bearing pyrimidinyl and pyrazolyl moieties as a promising heterocycles

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Abstract

In the present investigation, ten new 2-((3-aryl-1-phenyl-1H-pyrazol-4-yl)methylene)-1-(4,6-dimethylpyrimidin-2-yl)hydrazine (3a–j) having pyrimidinyl and pyrazolyl moieties were synthesized. Structures of all compounds were confirmed by their spectral and elemental data. Most of the tested compounds were found to be significantly more effective against bacterial strains Staphylococcus aureus, Bacillus subtilis and Pseudomonas aeruginosa than the reference drug ciprofloxacin. All the newly synthesized compounds were found to be more potent antifungal agents than reference drug against Candida albicans, whereas except 3e all other compounds also shown good activity against Saccharomyces cerevisiae.

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Acknowledgments

The Authors are thankful to Kurukshetra University, Kurukshetra for the financial assistance to carry out the work.

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Authors and Affiliations

  1. Department of Chemistry, Kurukshetra University, Kurukshetra, 136119, Haryana, India

    Raj Kamal & Vipan Kumar

  2. Department of Microbiology, Kurukshetra University, Kurukshetra, 136119, Haryana, India

    Vikas Kumar

  3. Vaidyanath Research Training and Diagnostic Centre, Kurukshetra, 136118, Haryana, India

    Kamal Rai Aneja

  4. Seth Jai Parkash Mukad Lal Institute of Engineering and Technology, Radaur, Yamauna Nagar, Haryana, India

    Vikas Bhardwaj

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  1. Raj Kamal
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  2. Vipan Kumar
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  3. Vikas Bhardwaj
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  4. Vikas Kumar
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  5. Kamal Rai Aneja
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Correspondence to Raj Kamal.

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Kamal, R., Kumar, V., Bhardwaj, V. et al. Synthesis, characterization and in vitro antimicrobial evaluation of some novel hydrazone derivatives bearing pyrimidinyl and pyrazolyl moieties as a promising heterocycles. Med Chem Res 24, 2551–2560 (2015). https://doi.org/10.1007/s00044-014-1313-5

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