Abstract
Pyrido[2,3-a]carbazoles were synthesized by multicomponent reactions using l-proline as catalyst. All the newly synthesized compounds were characterized by all spectral means. The in-vitro cytotoxicity of the newly synthesized pyrido[2,3-a]carbazoles was evaluated by SRB (sulforhodamine B) assay against MCF-7 (Breast Cancer), HeLa (cervix adenocarcinoma), and A549 (Human Lung adenocarcinoma). Cisplatin, a clinically used antitumor agent was also evaluated for standard. All the newly synthesized pyrido carbazoles showed moderate to good cytotoxic activity and their structural activity relationship has been established.
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Acknowledgments
This research supported by the Council of Scientific and Industrial Research, New Delhi for the award of Senior Research fellow (SRF) to T. Indumathi and “UGC-BSR One time grant” to Dr. K. J. Rajendra prasad are gratefully acknowledged. The authors thank Indian Institute of Technology Madras, Chennai for NMR and Indian Institute of Chemical Technology, Hyderabad for Mass spectral data.
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Indumathi, T., Rajendra Prasad, K.J. Multicomponent synthesis of pyrido[2,3-a]carbazoles and cytotoxic activity. Med Chem Res 23, 4345–4355 (2014). https://doi.org/10.1007/s00044-014-0999-8
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DOI: https://doi.org/10.1007/s00044-014-0999-8