Original Research

Medicinal Chemistry Research

, Volume 23, Issue 3, pp 1290-1299

Synthesis and evaluation of novel benzimidazole derivatives as antimicrobial agents

  • Deepkumar JoshiAffiliated withChemistry Research Laboratory, Chemistry Division, Sheth M. N. Science College
  • , Kalpesh ParikhAffiliated withChemistry Research Laboratory, Chemistry Division, Sheth M. N. Science College Email author 

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Abstract

Benzimidazole analogs bearing electron-withdrawing as well as electron-donating substituent were synthesized to achieve bioactive molecules with significant antimicrobial property. The desired compounds were prepared by multi-step synthesis process. The formation of intermediates and their corresponding derivatives (III 113 ) was confirmed by spectral characterization such as 1H NMR, 13C NMR, mass spectra, IR, and elemental analysis. The compounds were screened for their antimicrobial properties against a broad panel of Gram-positive and Gram-negative bacteria as well as fungi. From the SAR study data, it was observed that the derivatives with electron-withdrawing functional groups were more bioactive than that with electron-donating functional groups.

Keywords

Benzimidazole Antifungal Antibacterial MIC SAR study