Original Research

Medicinal Chemistry Research

, Volume 22, Issue 10, pp 4654-4662

Synthesis and antifungal activity of novel 7-O-substituted pyridyl-4-methyl coumarin derivatives

  • Xiaoyun ChaiAffiliated withDepartment of Organic Chemistry, School of Pharmacy, Second Military Medical University
  • , Shichong YuAffiliated withDepartment of Organic Chemistry, School of Pharmacy, Second Military Medical University
  • , Xiaoyan WangAffiliated withCenter for Laboratory Teaching, School of Pharmacy, Second Military Medical University
  • , Nan WangAffiliated withPharmacy Team, Administrative Brigade of Postgraduate, Second Military Medical University
  • , Zhanzhou ZhuAffiliated withPharmacy Team, Administrative Brigade of Postgraduate, Second Military Medical University
  • , Dazhi ZhangAffiliated withDepartment of Organic Chemistry, School of Pharmacy, Second Military Medical University
  • , Qiuye WuAffiliated withDepartment of Organic Chemistry, School of Pharmacy, Second Military Medical University
  • , Yongbing CaoAffiliated withDrug Research Center, School of Pharmacy, Second Military Medical University
  • , Qingyan SunAffiliated withDepartment of Organic Chemistry, School of Pharmacy, Second Military Medical University Email author 

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Abstract

A new series of 7-O-substituted pyridyl-4-methyl coumarin derivatives were synthesized and characterized based on their spectral data. All the target compounds were evaluated for their in vitro antifungal activity against eight important fungal pathogens. This study showed that the introduction of the substituted pyridyl moiety at the 7-hydroxy position of coumarin could enhance the antifungal activities. It also indicated that a bulky substituent was not beneficial to the antifungal activity of those coumarin derivatives.

Keywords

Coumarin derivatives Synthesis Antifungal activity Pechmann reaction