, Volume 22, Issue 10, pp 4654-4662
Date: 17 Jan 2013

Synthesis and antifungal activity of novel 7-O -substituted pyridyl-4-methyl coumarin derivatives

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


A new series of 7-O-substituted pyridyl-4-methyl coumarin derivatives were synthesized and characterized based on their spectral data. All the target compounds were evaluated for their in vitro antifungal activity against eight important fungal pathogens. This study showed that the introduction of the substituted pyridyl moiety at the 7-hydroxy position of coumarin could enhance the antifungal activities. It also indicated that a bulky substituent was not beneficial to the antifungal activity of those coumarin derivatives.