Medicinal Chemistry Research

, Volume 22, Issue 10, pp 4654–4662

Synthesis and antifungal activity of novel 7-O-substituted pyridyl-4-methyl coumarin derivatives

Authors

  • Xiaoyun Chai
    • Department of Organic ChemistrySchool of Pharmacy, Second Military Medical University
  • Shichong Yu
    • Department of Organic ChemistrySchool of Pharmacy, Second Military Medical University
  • Xiaoyan Wang
    • Center for Laboratory TeachingSchool of Pharmacy, Second Military Medical University
  • Nan Wang
    • Pharmacy Team, Administrative Brigade of PostgraduateSecond Military Medical University
  • Zhanzhou Zhu
    • Pharmacy Team, Administrative Brigade of PostgraduateSecond Military Medical University
  • Dazhi Zhang
    • Department of Organic ChemistrySchool of Pharmacy, Second Military Medical University
  • Qiuye Wu
    • Department of Organic ChemistrySchool of Pharmacy, Second Military Medical University
  • Yongbing Cao
    • Drug Research Center, School of Pharmacy, Second Military Medical University
    • Department of Organic ChemistrySchool of Pharmacy, Second Military Medical University
Original Research

DOI: 10.1007/s00044-013-0470-2

Cite this article as:
Chai, X., Yu, S., Wang, X. et al. Med Chem Res (2013) 22: 4654. doi:10.1007/s00044-013-0470-2

Abstract

A new series of 7-O-substituted pyridyl-4-methyl coumarin derivatives were synthesized and characterized based on their spectral data. All the target compounds were evaluated for their in vitro antifungal activity against eight important fungal pathogens. This study showed that the introduction of the substituted pyridyl moiety at the 7-hydroxy position of coumarin could enhance the antifungal activities. It also indicated that a bulky substituent was not beneficial to the antifungal activity of those coumarin derivatives.

Keywords

Coumarin derivatives Synthesis Antifungal activity Pechmann reaction

Copyright information

© Springer Science+Business Media New York 2013