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Novel salicylamide derivatives incorporating neonicotinoid pharmacophore: design, synthesis, characterization, and biological evaluation

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Abstract

A series of novel salicylamide derivatives containing neonicotinoid pharmacophore were designed and synthesized via multi-step reactions. These compounds were characterized by satisfied spectrum analyses mainly including 1H NMR and ESI-MS. The preliminary bioassays indicated that some of target compounds exhibited excellent insecticidal activities against Heliothis armigera and Plutella xylostella at the dosage of 31.25 μg/mL.

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Acknowledgments

We gratefully acknowledge the support of this work by the Projects in the Youth Science Foundation of Hubei Academy of Agricultural Sciences (2011NKYJJ19) and the National Natural Science Foundation of China (31000867). The authors also gratefully acknowledge the partial support from Hubei Biopesticide Engineering Research Centre.

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Authors and Affiliations

  1. National Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Wuhan, 430064, People’s Republic of China

    Shaoyong Ke, Zhigang Zhang, Tong Long, Ying Liang & Ziwen Yang

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  1. Shaoyong Ke
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  2. Zhigang Zhang
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  3. Tong Long
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  4. Ying Liang
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  5. Ziwen Yang
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Corresponding author

Correspondence to Shaoyong Ke.

Additional information

Shaoyong Ke and Zhigang Zhang contributed equally to this study.

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Ke, S., Zhang, Z., Long, T. et al. Novel salicylamide derivatives incorporating neonicotinoid pharmacophore: design, synthesis, characterization, and biological evaluation. Med Chem Res 22, 3621–3628 (2013). https://doi.org/10.1007/s00044-012-0380-8

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  • DOI: https://doi.org/10.1007/s00044-012-0380-8

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