Abstract
The present work is aimed to study the interactions between cefpirome and hypoglycemic agents (gliquidone, metformin, and pioglitazone) by chromatographic and spectroscopic techniques. In the first case, reversed-phase high-performance liquid chromatographic methods have been developed, validated for the simultaneous determination of cefpirome with hypoglycemic agents, and was applied for interaction studies. These interactions were carried out in simulated gastric juice (pH1), buffers of pH 4, 7.4, and 9 at 37 °C for 3 h. In the second case, cefpirome–hypoglycemic agents complexes were synthesized and elucidated on the basis of FT-IR, 1H-NMR, and 13C-NMR studies.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Arayne MS, Sultana N (1993) Erythromycin antacid interactions. Die Pharmazie 48:599–602
Arayne MS, Sultana N, Nawaz M (2006) A RP-HPLC method for the assay of cefpirome and its application in drug-metal interaction studies. Pak J Pharm Sci 19:39–44
Arayne MS, Sultana N, Nawaz M (2008) Simultaneous quantitation of cefpirome with levocetirizine or cetirizine in pharmaceutical formulations and human plasma by RP-HPLC. J Anal Chem 63:881–887
Bertran MA, Bruckner DA, Young LS (1984) In vitro activity of HR 810, a new cephalosporin. Antimicrob Agents Chemother 26:277–279
Block J, Beale JM (2004) Wilson and Gisvold’s textbook of organic medicinal and pharmaceutical chemistry. Lippincott Williams & Wilkins, London
Breilh D, Lavallee C, Fatta A, Ducint D, Cony-Makhoul P, Saux MC (1999) Determination of cefepime and cefpirome in human serum by high-performance liquid chromatography using an ultrafiltration for antibiotics serum extraction. J Chromatogr B 734:121–127
Girardin E (1992) Hypoglycemies indutes par les sulfamides hypoglycemiants. Ann Med Interne 143:11–17
Goldstein EJC, Citron DM (1985) Comparative in vitro inhibitory and killing activity of cefpirome, ceftazidime, and cefotaxime against Pseudomonas aeruginosa, enterococci, Staphylococcus epidermidis, and methicillin-susceptible and -resistant and tolerant and nontolerant Staphylococcus aureus. Antimicrob Agents Chemother 28:160–162
Gregory LK, Virginia AJ, Isabel RH, Thomas GW (1992) Microanalytical high-performance liquid chromatographic assay for cefpirome in human milk and urine. J Chromatogr B 574:356–360
Hayashi H, Yamashita T, Nakata T, Huji T, Kojima T, Katayama H, Ishikawa M (2002) Cefpirome sulphate for gynaecological infections and prophylaxis of non-laparotomy surgery in patients with benign disease. Int J Antimicrob Agents 19:405–411
Herman RJ (1999) Drug interactions and the statins. CMAJ 161:1281–1286
Hundal RS, Inzucchi SE (2003) Metformin: new understandings, new uses. Drugs 63:1879–1894
Jones RN, Thornsberry C, Barry AL, Ayers L, Brown S, Daniel J, Fuchs PC, Gavan TL, Geriach EH, Mastsen JM, Reller LB, Sommers HM (1984) Disk diffusion testing, quality control guidelines, and antimicrobial spectrum of HR 810, a fourth-generation cephalosporin, in clinical microbiology laboratories. J Clin Microbiol 20:409–412
Jones RN, Pfaller MA, Allen SD, Gerlach EH, Fuchs PC, Aldridge KE (1999) Antimicrobial activity of cefpirome. An update compared to five third-generation cephalosporins against nearly 6000 recent clinical isolates from five medical centers. Diagn Microbiol Infect Dis 14:361–364
Legg EF, Guy JM (1992) Serum creatinine assays in patients receiving the antibiotic cefpirome (HR 810): a study of three different routine methods compared with a specific HPLC method. Med Lab Sci 49:248–251
Nawaz M, Arayne MS, Sultana N (2012) Monitoring of cefpirome-antioxidant interaction studies using RP-HPLC. Med Chem Res 21:2181–2184
O’Byrne S, Feely J (1990) Effect of drugs on glucose tolerance in non-insulin-dependent diabetics (part1). Drugs 40:6–18
Paroni R, Comuzzi B, Arcelloni C, Brocco S, Kreutzenberg S, Tiengo A, Ciucci A, Beck-Peccoz P, Genovese S (2000) Comparison of capillary electrophoresis with HPLC for diagnosis of factitious hypoglycemia. Clin Chem 46:1773–1780
Scheen AJ (1996) Clinical pharmacokinetics of metformin. Clin Pharmacokinet 30:359–371
Seibert G, Limbert M, Winkler I, Dick T (1983) The Antibacterial activity in vitro and beta-lactamase stability of the new cephalosporin HR 810 in comparison with five other cephalosporins and two aminoglycosides. Infection 11:275–279
Sener A, Akkan A, Malaisse W (1995) Standardized procedure for the assay and identification of hypoglycemic sulfonylureas in human plasma. Acta Diabetol 32:64–68
Strausbauch M, Xu S, Ferguson J, Nunez M, Landers J (1995) Concentration and separation of hypoglycemic drugs using solid-phase extraction-capillary electrophoresis. J Chromatogr A 717:279–291
Sultana N, Arayne MS, Iftikhar B, Nawaz M (2008) A new RP-HPLC method for monitoring of atenolol: application to atenolol metal interaction studies. J Chem Soc Pak 30:113–118
Thevis M, Geyer H, Schanzer W (2005) Identification of oral antidiabetics and their metabolites in human urine by liquid chromatography/tandem mass spectrometry-a matter for doping control analysis. Rapid Commun Mass Spectrom 19:928–936
Turley CP, Kearns GL, Jacobs RF (1988) Microanalytical high-performance liquid chromatography assay for cefpirome (HR 810) in serum. Antimicrob Agents Chemother 32:1481–1483
Uihlein M, Klesel N, Seeger K (1988) Determination of cefpirome (HR 810) in serum and urine. Infection 16:135–140
Vassilis E, Tsantili-Kakoulidou A, Michael K (2003) Determination of the dissociation constants of the cephalosporins cefepime and cefpirome using UV spectrometry and pH potentiometry. J Pharm Biomed Anal 31:1119–1128
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nawaz, M., Arayne, M.S. & Sultana, N. Drug interactions and synthesis of cefpirome with hypoglycemic agents. Med Chem Res 22, 3581–3588 (2013). https://doi.org/10.1007/s00044-012-0365-7
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00044-012-0365-7