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Computational evaluation and experimental verification of antibacterial activity of some β-lactams: advantages and limitations

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Abstract

Herein, mono and bicyclic β-lactams are computationally evaluated and experimentally verified for in vitro antimicrobial activity. The compounds prepared were tested against various Gram-positive and Gram-negative bacterial species such as Escherichia coli, Staphylococcus citrus, Klebsiella pneumoniae, and Bacillus subtilis. Some of these compounds show potential antimicrobial activities. This study would greatly help to pharmacomodultate the antibiotics.

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Acknowledgments

The authors are highly thankful to the Shiraz University Research Council for financial support (Grant No. 87-GR-SC-23). Prof. T. Ben Hadda would like to thank ACTELION; the Biopharmaceutical Company of Swiss, for the molecular properties calculations.

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Authors and Affiliations

  1. Department of Chemistry, College of Sciences, Shiraz University, 71454, Shiraz, Iran

    Aliasghar Jarrahpour

  2. Department of Chemistry, RTM Nagpur University, Nagpur, 440033, India

    Javed Sheikh

  3. Laboratoire Chimie des Matériaux, Faculté des Sciences, Université Mohammed Premier, 60000, Oujda, Morocco

    Ibrahim El-Mounsi, Rahima Mouhoub & Taibi Ben Hadda

Authors
  1. Aliasghar Jarrahpour
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  2. Javed Sheikh
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  3. Ibrahim El-Mounsi
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  4. Rahima Mouhoub
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  5. Taibi Ben Hadda
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Corresponding authors

Correspondence to Javed Sheikh or Taibi Ben Hadda.

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Jarrahpour, A., Sheikh, J., El-Mounsi, I. et al. Computational evaluation and experimental verification of antibacterial activity of some β-lactams: advantages and limitations. Med Chem Res 22, 1197–1202 (2013). https://doi.org/10.1007/s00044-012-0126-7

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  • DOI: https://doi.org/10.1007/s00044-012-0126-7

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