Medicinal Chemistry Research

, Volume 22, Issue 2, pp 900–904

Synthesis of novel benzimidazole derivatives: as potent analgesic agent

Authors

    • Department of Pharmaceutical TechnologyMeerut Institute of Engineering and Technology
  • Pramod Kumar Sharma
    • Department of Pharmaceutical TechnologyMeerut Institute of Engineering and Technology
  • Niranjan Kaushik
    • Department of Pharmaceutical TechnologyMeerut Institute of Engineering and Technology
Original Research

DOI: 10.1007/s00044-012-0083-1

Cite this article as:
Dixit, S., Sharma, P.K. & Kaushik, N. Med Chem Res (2013) 22: 900. doi:10.1007/s00044-012-0083-1

Abstract

1-(1-Alkyl-6-substituted-1H-benzimidazol-2-yl)-naphthalen-2-ols have been synthesized using o-phenylinediamine and naphthaldehyde in the presence of sodium hydride and THF. 1-(1-Alkyl-6-substituted-1H-benzimidazol-2-yl)-naphthalen-2-ols were evaluated for the analgesic activity by tail flick method in rats. Synthesized1-(1-alkyl-6-substituted-1H-benzimidazol-2-yl)-naphthalen-2-ols in doses of 50 mg/kg increased the pain threshold significantly after 0, 30, 60, 90, and 120 min of administration in the tail flick model. Compounds B3a, B2b, and B1b showed time-dependent action in all the experimental models. The present study indicates that Compounds B3a, B2b, and B1b show analgesic properties.

Keywords

Benzimidazole derivatives Analgesic activity Tail flick method Naphthalene derivatives

Supplementary material

44_2012_83_MOESM1_ESM.pdf (1002 kb)
Supplementary material 1 (PDF 1001 kb)

Copyright information

© Springer Science+Business Media, LLC 2012