Medicinal Chemistry Research

, Volume 22, Issue 2, pp 900–904

Synthesis of novel benzimidazole derivatives: as potent analgesic agent

  • Shushank Dixit
  • Pramod Kumar Sharma
  • Niranjan Kaushik
Original Research

DOI: 10.1007/s00044-012-0083-1

Cite this article as:
Dixit, S., Sharma, P.K. & Kaushik, N. Med Chem Res (2013) 22: 900. doi:10.1007/s00044-012-0083-1

Abstract

1-(1-Alkyl-6-substituted-1H-benzimidazol-2-yl)-naphthalen-2-ols have been synthesized using o-phenylinediamine and naphthaldehyde in the presence of sodium hydride and THF. 1-(1-Alkyl-6-substituted-1H-benzimidazol-2-yl)-naphthalen-2-ols were evaluated for the analgesic activity by tail flick method in rats. Synthesized1-(1-alkyl-6-substituted-1H-benzimidazol-2-yl)-naphthalen-2-ols in doses of 50 mg/kg increased the pain threshold significantly after 0, 30, 60, 90, and 120 min of administration in the tail flick model. Compounds B3a, B2b, and B1b showed time-dependent action in all the experimental models. The present study indicates that Compounds B3a, B2b, and B1b show analgesic properties.

Keywords

Benzimidazole derivativesAnalgesic activityTail flick methodNaphthalene derivatives

Supplementary material

44_2012_83_MOESM1_ESM.pdf (1002 kb)
Supplementary material 1 (PDF 1001 kb)

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Shushank Dixit
    • 1
  • Pramod Kumar Sharma
    • 1
  • Niranjan Kaushik
    • 1
  1. 1.Department of Pharmaceutical TechnologyMeerut Institute of Engineering and TechnologyMeerutIndia