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Iodine catalyzed one-pot synthesis of chloro-substituted linear and angular indoloquinolines and in vitro antiproliferative activity study of different indoloquinolines

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Abstract

This article describes a facile one-pot synthesis of different chloro-substituted linear and angular indoloquinolines using iodine as a catalyst and in vitro antiproliferative activity of these chloro-substituted indoloquinolines (3e and 3f) and some indolo[2,3-b]quinolines (3a–d) against human hepatocellular carcinoma HepG2 and human breast carcinoma MCF-7 cells. Anti-proliferative assay against human hepatocellular carcinoma HepG2 and human breast carcinoma MCF-7 cells indicated methyl-substituted 6H-indolo[2,3-b]quinoline 3c to be the most active and the parent 6H-indolo[2,3-b]quinoline 3a to be the least active, while the other compounds including the different chloro derivatives exhibited only intermediate activity.

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Acknowledgments

We thank the CSIR, New Delhi for the financial support and one of us (P. T. P) is thankful to CSIR for awarding Senior Research Fellowship.

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Authors and Affiliations

  1. National Institute of Oceanography, Dona Paula, Goa, 403 004, India

    Prakash T. Parvatkar

  2. Department of Chemistry, Goa University, Taleigao Plateau, Goa, 403 206, India

    Prakash T. Parvatkar & Santosh G. Tilve

  3. National Centre for Cell Science, Ganeshkhind, Pune, 411 007, India

    Amrendra Kumar Ajay & Manoj Kumar Bhat

  4. National Institute of Oceanography, Regional Centre, Kochi, 682 018, India

    Perunninakulath S. Parameswaran

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  1. Prakash T. Parvatkar
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  2. Amrendra Kumar Ajay
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  3. Manoj Kumar Bhat
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  4. Perunninakulath S. Parameswaran
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  5. Santosh G. Tilve
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Correspondence to Prakash T. Parvatkar, Manoj Kumar Bhat, Perunninakulath S. Parameswaran or Santosh G. Tilve.

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Parvatkar, P.T., Ajay, A.K., Bhat, M.K. et al. Iodine catalyzed one-pot synthesis of chloro-substituted linear and angular indoloquinolines and in vitro antiproliferative activity study of different indoloquinolines. Med Chem Res 22, 88–93 (2013). https://doi.org/10.1007/s00044-012-0015-0

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  • DOI: https://doi.org/10.1007/s00044-012-0015-0

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