Synthesis and antimicrobial activity of novel derivatives of Biginelli pyrimidines
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- Sedaghati, B., Fassihi, A., Arbabi, S. et al. Med Chem Res (2012) 21: 3973. doi:10.1007/s00044-011-9931-7
A series of novel Biginelli pyrimidines was prepared and evaluated for antimicrobial activity. Weak inhibitory activity (MIC = 128 μg/ml) was observed from 3b and 8b, against S. aureus and P. aeruginosa, respectively. Moderate antifungal agents: 4c, 4d, 4e with MIC = 32 μg/ml, 3d, 7b, and 8b with MIC = 64 μg/ml against C.albicans were determined. 4c, 4d, 4e, and 7b proved to be moderate antifungals against A. niger with MIC = 64 μg/ml.