Original Research

Medicinal Chemistry Research

, Volume 21, Issue 12, pp 3973-3983

Synthesis and antimicrobial activity of novel derivatives of Biginelli pyrimidines

  • Bita SedaghatiAffiliated withDepartment of Medicinal Chemistry and Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences
  • , Afshin FassihiAffiliated withDepartment of Medicinal Chemistry and Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences
  • , Shirin ArbabiAffiliated withDepartment of Medicinal Chemistry and Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences
  • , Mahnaz RanjbarAffiliated withDepartment of Chemistry, Faculty of Sciences, University of Isfahan
  • , Hamid Reza MemarianAffiliated withDepartment of Chemistry, Faculty of Sciences, University of Isfahan
  • , Lotfollah SaghaieAffiliated withDepartment of Medicinal Chemistry and Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences
  • , Adel OmidiAffiliated withDepartment of Medicinal Chemistry and Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences
  • , Alireza SardariAffiliated withDepartment of Medicinal Chemistry and Isfahan Pharmaceutical Research Center, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences
  • , Mohammad JalaliAffiliated withSchool of Health, Isfahan University of Medical Sciences
    • , Daryoush AbediAffiliated withDepartment of Pharmaceutical Biotechnology, School of Pharmacy and Pharmaceutical Sciences, Isfahan University of Medical Sciences Email author 

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Abstract

A series of novel Biginelli pyrimidines was prepared and evaluated for antimicrobial activity. Weak inhibitory activity (MIC = 128 μg/ml) was observed from 3b and 8b, against S. aureus and P. aeruginosa, respectively. Moderate antifungal agents: 4c, 4d, 4e with MIC = 32 μg/ml, 3d, 7b, and 8b with MIC = 64 μg/ml against C. albicans were determined. 4c, 4d, 4e, and 7b proved to be moderate antifungals against A. niger with MIC = 64 μg/ml.

Keywords

Antibacterial activity Antifungal activity 1,2,3,4-Tetrahydropyrimidine-5-carboxamides 1,2,3,4-Tetrahydropyrimidine-5-carboxylate esters