Abstract
A series of new heterocyclic derivatives having a pyridine nucleus were synthesized. 4-(5-(2-Chlorophenyl)-4H-1,2,4-triazol-3-yl)pyridine (7c) and 4-(5-(2-Nitrophenyl)-4H-1,2,4-triazol-3-yl)pyridine (7d) presented the best analgesic profie of this series in hot-plate, tail-flick, and formalin-induced licking tests, which was partially prevented by pretreatment with mecamylamine, a nicotinic receptor antagonist.
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One of the authors (MND) is thankful to the University of Pune for the grant for this project, and Dr. Ashok Bhosale for providing the necessary facilities.
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Nigade, G., Chavan, P. & Deodhar, M. Synthesis and analgesic activity of new pyridine-based heterocyclic derivatives. Med Chem Res 21, 27–37 (2012). https://doi.org/10.1007/s00044-010-9489-9
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DOI: https://doi.org/10.1007/s00044-010-9489-9