Abstract
The chalcone 3 was synthesized from 3-acetyl-4-hydroxy coumarin and 3-formylchromone by refluxing in ethanol in the presence of a catalytic amount of pyridine. 3 was converted to bipyrazoles 4a-b by treatment with hydrazine and phenylhydrazine. The compounds were screened for their antibacterial activity.
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Acknowledgement
Financial assistance from UGC, New Delhi, is gratefully acknowledged. The authors would also like to thank SAIF, CDRI, Lucknow for spectral data, Dr. Iqbal Ahmad, Department of agricultural microbiology, Aligarh Muslim University, Aligarh for biological screening and Prof. N. U. Khan, Department of Chemistry, A.M.U. Aligarh for sincere advice.
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Siddiqui, Z.N., Asad, M. & Praveen, S. Synthesis and biological activity of heterocycles from chalcone. Med Chem Res 17, 318–325 (2008). https://doi.org/10.1007/s00044-007-9067-y
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DOI: https://doi.org/10.1007/s00044-007-9067-y