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PHENYLPYRUVIC ACID DERIVATIVES AS ENZYME INHIBITORS: THERAPEUTIC POTENTIAL ON MACROPHAGE MIGRATION INHIBITORY FACTOR

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Abstract

Phenylpyruvic acid derivatives are obtained by hydrolyzing aromatic Z/E azlactones. Keto tautomers interact with enzyme systems such as phenylalanine dehydrogenase or carboxypeptidase A whereas enol tautomers are potential inhibitors on the phenylpyruvate tautomerase activity catalysed by Macrophage Migration Inhibitory Factor (MIF). MIF being a key molecule in immune and inflammatory processes several structures with reasonable interactions with MIF and protocol for specific synthesis are presented.

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Authors and Affiliations

  1. LPTC, UMR 5472 CNRS, University of Bordeaux France, 1, 351 Cours de la Libération F-33405 TALENCE CEDEX, France

    Alain J.M. Carpy

  2. Dept of Pharmacy and Pharmacology, University of the Witwatersrand, 7 York Road, PARKTOWN 2193, Republic of South Africa

    Petrus P. Haasbroeck

  3. Pharmacology, Faculty of Health Science, Potchefstroom University, POTCHEFSTROOM 2520, Republic of South Africa

    Douglas W. Oliver

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  1. Alain J.M. Carpy
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  2. Petrus P. Haasbroeck
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  3. Douglas W. Oliver
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Correspondence to Alain J.M. Carpy.

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Carpy, A., Haasbroeck, P. & Oliver, D. PHENYLPYRUVIC ACID DERIVATIVES AS ENZYME INHIBITORS: THERAPEUTIC POTENTIAL ON MACROPHAGE MIGRATION INHIBITORY FACTOR. Med Chem Res 13, 565–577 (2004). https://doi.org/10.1007/s00044-004-0102-y

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  • DOI: https://doi.org/10.1007/s00044-004-0102-y

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