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Development of anticancer agents targeting the Hedgehog signaling

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Abstract

Hedgehog signaling is an evolutionarily conserved pathway which is essential in embryonic and postnatal development as well as adult organ homeostasis. Abnormal regulation of Hedgehog signaling is implicated in many diseases including cancer. Consequently, substantial efforts have made in the past to develop potential therapeutic agents that specifically target the Hedgehog signaling for cancer treatment. Here, we review the therapeutic agents for inhibition of the Hedgehog signaling and their clinical advances in cancer treatment.

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Acknowledgements

This work was supported by the seed fund of College of Veterinary Medicine at Western University of Health Sciences and Faculty Development Grant from Chinese American Faculty Association of Southern California (CAFA). The authors would like to acknowledge ChemAxon (http://www.chemaxon.com) for providing an academic license to their software.

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  1. College of Life Science, Yan’an University, Yan’an, 716000, Shaanxi, China

    Xiangqian Zhang & Ye Tian

  2. Medical College, Yan’an University, Yan’an, 716000, Shaanxi, China

    Yanling Yang

  3. College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA, 91766, USA

    Jijun Hao

  4. Graduate College of Biomedical Sciences, Western University of Health Sciences, Pomona, CA, 91766, USA

    Jijun Hao

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Zhang, X., Tian, Y., Yang, Y. et al. Development of anticancer agents targeting the Hedgehog signaling. Cell. Mol. Life Sci. 74, 2773–2782 (2017). https://doi.org/10.1007/s00018-017-2497-x

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