Multi-author review

Cellular and Molecular Life Sciences

, Volume 70, Issue 10, pp 1753-1761

Vascular endothelial growth factors (VEGFs) and stroke

  • David A. GreenbergAffiliated withBuck Institute for Research on Aging Email author 
  • , Kunlin JinAffiliated withBuck Institute for Research on AgingDepartment of Pharmacology and Neuroscience, University of North Texas Health Science Center

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Abstract

Vascular endothelial growth factors (VEGFs) have been shown to participate in atherosclerosis, arteriogenesis, cerebral edema, neuroprotection, neurogenesis, angiogenesis, postischemic brain and vessel repair, and the effects of transplanted stem cells in experimental stroke. Most of these actions involve VEGF-A and the VEGFR-2 receptor, but VEGF-B, placental growth factor, and VEGFR-1 have been implicated in some cases as well. VEGF signaling pathways represent important potential targets for the acute and chronic treatment of stroke.

Keywords

Vascular endothelial growth factor Stroke Ischemia Neuroprotection Neurogenesis Angiogenesis