Cellular and Molecular Life Sciences

, Volume 64, Issue 22, pp 2975–2984

Melanocyte fate in neural crest is triggered by Myb proteins through activation of c-kit

  • V. Karafiat
  • M. Dvorakova
  • P. Pajer
  • V. Cermak
  • M. Dvorak
Research Article

DOI: 10.1007/s00018-007-7330-5

Cite this article as:
Karafiat, V., Dvorakova, M., Pajer, P. et al. Cell. Mol. Life Sci. (2007) 64: 2975. doi:10.1007/s00018-007-7330-5

Abstract.

The c-myb proto-oncogene and its oncogenic derivative v−mybAMV encode transcriptional regulators engaged in the commitment of hematopoietic cells. While the c-Myb protein is important for the formation and differentiation of various progenitors, the v−MybAMV oncoprotein induces in chicks a progression and transformation of the single (monoblastic) cell lineage. Here we present the first evidence of cell fate-directing abilities of c-Myb and v−MybAMV proteins in avian neural crest (NC), where both proteins determine melanocytogenesis. The increased concentration of c-Myb induces progression into dendritic melanocytes and differentiation. The v-myb oncogene converts essentially all NC cells into melanocytes and causes their transformation. Both Myb proteins activate in NC cells expression of the c-kit gene and stem cell factor c-Kit signaling – one of the essential pathways in melanocyte development. These observations suggest that the c-myb-c-kit pathway represents a common regulatory scheme for both hematopoietic and neural progenitors and establishes a novel experimental model for studies of melanocytogenesis and melanocyte transformation.

Keywords.

c-myb proto-oncogenev-mybAMVoncogeneneural crestcell fate determinationmelanocytesc-kit signal

Copyright information

© Birkhaueser 2007

Authors and Affiliations

  • V. Karafiat
    • 1
  • M. Dvorakova
    • 1
  • P. Pajer
    • 1
  • V. Cermak
    • 1
  • M. Dvorak
    • 1
  1. 1.Department of Molecular VirologyInstitute of Molecular GeneticsPrague 4Czech Republic