Review

Cellular and Molecular Life Sciences CMLS

, Volume 62, Issue 9, pp 971-988

Surface exposure of phosphatidylserine in pathological cells

  • R. F. A. ZwaalAffiliated withDept of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University Email author 
  • , P. ComfuriusAffiliated withDept of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University
  • , E. M. BeversAffiliated withDept of Biochemistry, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University

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Abstract.

The asymmetric phospholipid distribution in plasma membranes is normally maintained by energy-dependent lipid transporters that translocate different phospholipids from one monolayer to the other against their respective concentration gradients. When cells are activated, or enter apoptosis, lipid asymmetry can be perturbed by other lipid transporters (scramblases) that shuttle phospholipids non-specifically between the two monolayers. This exposes phosphatidylserine (PS) at the cells’ outer surface. Since PS promotes blood coagulation, defective scramblase activity upon platelet stimulation causes a bleeding disorder (Scott syndrome). PS exposure also plays a pivotal role in the recognition and removal of apoptotic cells via a PS-recognizing receptor on phagocytic cells. Furthermore, expression of PS at the cell surface can occur in a wide variety of disorders. This review aims at highlighting how PS expression in different cells may complicate a variety of pathological conditions, including those that promote thromboembolic complications or produce aberrations in apoptotic cell removal.

Key words.

Membrane asymmetry lipid scramblase aminophospholipid translocase apoptosis blood coagulation erythrocytes platelets