Cellular and Molecular Life Sciences CMLS

, Volume 61, Issue 12, pp 1455–1474

Protein N-terminal methionine excision

Review

DOI: 10.1007/s00018-004-3466-8

Cite this article as:
Giglione, C., Boularot, A. & Meinnel, T. CMLS, Cell. Mol. Life Sci. (2004) 61: 1455. doi:10.1007/s00018-004-3466-8

Abstract

N-terminal methionine excision (NME) is the major proteolytic pathway responsible for the diversity of N-terminal amino acids in proteins. Dedicated NME components have been identified in all organisms, in all compartments in which protein synthesis occurs: cytoplasm, plastids and mitochondria. Recent studies have revealed that NME is regulated at various levels and plays an important role in controlling protein turnover. NME is essential in Eubacteria and lower eukaryotes and is the target of many natural and synthetic inhibitors. Such inhibitors have considerable potential for use in the treatment of various human diseases, from cancer to bacterial and parasitic infections.

Peptide deformylaseaminopeptidasedrugmetal cationmetalloproteasehuman pathogenesistherapeutics

Copyright information

© Birkhäuser-Verlag Basel 2004

Authors and Affiliations

  1. 1.Protein Maturation Group, Institut des Sciences du Végétal, UPR2355Centre National de la Recherche Scientifique, Bâtiment 23Gif-sur-Yvette cedexFrance