, Volume 48, Issue 10, pp 516-523

Anti-T cell strategies in asthma

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Abstract.

Chronic asthma is characterised by inflammation of the airways. Although corticosteroids are effective therapy, the risk benefit ratio is unacceptable in a minority of patients requiring chronic and high dose corticosteroid therapy because of adverse effects. There is accumulating circumstantial evidence that the CD4+ T-cell plays a central role in the pathogenesis of chronic asthma. Therapeutic strategies directed specifically at this cell type may offer a novel approach. Controlled clinical trials of cyclosporin A were effective in both chronic asthma and in a model of provoked asthma. Other immunomodulators such as FK506, rapamycin and mycophenolic acid may be useful given their modes of action on the T lymphocyte. The use of monoclonal antibody therapy directed towards these cells and T-cell peptide specific immunotherapy have been evaluated in preliminary studies and demonstrated promising results. Strategies targeting T cell co-stimulatory molecules and T-cell derived cytokines may be of therapeutic utility.

Received 27 May 1998; returned for revision 21 August 1998; returned for final revision 9 June 1999; accepted by M. J. Parnham 14 July 1999.