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The biological function and significance of CD74 in immune diseases

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Abstract

CD74 (MHC class II invariant chain, Ii) is a non-polymorphic type II transmembrane glycoprotein. It is clear that, in addition to be an MHC class II chaperone, CD74 has a diversity of biological functions in physiological and pathological situations. CD74 also participates in other non-MHC II protein trafficking, such as angiotensin II type I receptor. In addition, CD74 is a cell membrane high-affinity receptor for macrophage migration inhibitory factor (MIF), D-dopachrome tautomerase (D-DT/MIF-2) and bacterial proteins. CD74 also regulates T-cell and B-cell developments, dendritic cell (DC) motility, macrophage inflammation, and thymic selection. The activation of receptor complex CD74/CD44 may lead to multiple intracellular signal pathways, such as the activation of the extracellular signal regulated kinase (ERK) 1 and 2, the PI3K-Akt signal transduction cascade, NFκB, and the AMP-activated protein kinase (AMPK) pathway. CD74 plays important roles in many inflammatory diseases, such as liver fibrosis, type I diabetes, systemic lupus erythematosus, and Alzheimer disease. In this study, we will focus on the immunological functions of CD74 molecules and its roles in immune-relevant disorders.

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Acknowledgments

The authors wish to thank Dr. Yuzhu Hou for his kind review of the manuscript, and Mrs. Ling Li for her excellent laboratory management. This work was supported by grants from the National Natural Science Foundation of China for General and Key Programs (C81130055, C81072396, Y.Z.), Beijing Municipal Hospital Authority “Yangfan Program” (ZYLX201408, X.Z.), Knowledge Innovation Program of Chinese Academy of Sciences (XDA04020202-19, Y.Z.), and the CAS/SAFEA International Partnership Program for Creative Research Teams (Y.Z.).

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  1. Transplantation Biology Research Division, State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beichen West Road 1-5, Chaoyang District, Beijing, 100101, China

    Huiting Su & Yong Zhao

  2. University of Chinese Academy of Sciences, Beijing, China

    Huiting Su & Yong Zhao

  3. Department of Kidney Transplantation, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong, China

    Ning Na

  4. Department of Urology, Beijing Chaoyang Hospital, Capital Medical University, 8 Gong Ti Nan Road, Chaoyang District, Beijing, 100020, China

    Xiaodong Zhang

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  1. Huiting Su
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Correspondence to Xiaodong Zhang or Yong Zhao.

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Su, H., Na, N., Zhang, X. et al. The biological function and significance of CD74 in immune diseases. Inflamm. Res. 66, 209–216 (2017). https://doi.org/10.1007/s00011-016-0995-1

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  • DOI: https://doi.org/10.1007/s00011-016-0995-1

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