Background and objectives
Abstract
Altered immune response may be a part of the pathogenesis of preeclampsia. The few epidemiologic studies that have investigated the associations between genetic variations in the complement system genes and preeclampsia risk have reached inconsistent results. The aim of this study is to determine if polymorphisms in the complement system genes could influence the risk of preeclampsia.
Methods
We examined 51 SNPs in the C3, C5, C6, MASP1, MBL2 and CD55 genes and the risk of preeclampsia and its clinical subtypes in a nested case–control study of 203 preeclampsia cases and 233 controls.
Results
Both C6 and MASP1 were associated with the risk of preeclampsia. C6 (rs7444800, rs4957381) and MASP1 (rs1108450, rs3774282, rs698106) polymorphisms were associated with the risk of early-onset preeclampsia and severe preeclampsia, while MASP1 (rs1357134, rs698090) polymorphisms were associated with the risk of late-onset preeclampsia and severe preeclampsia.
Conclusions
Our study provided novel evidence that genetic variations in complement genes C6 and MASP1were associated with preeclampsia risk, and that the risk varied by preeclampsia subtypes.
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Acknowledgments
This work was supported by the National Institutes of Health (Grant No. K02HD70324), the National Natural Science Foundation of China (Grant No. 81473061), the Natural Science Foundation of Shanxi province (Grant No. 2013021033-2), the “100 Talent Plan” Award of Shanxi Province, and finally the “10 Talent Plan” Award of Shanxi Medical University.
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Responsible Editor: John Di Battista.
S. Wang and Y. Zhang are contributed equally to this work.
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Wu, W., Yang, H., Feng, Y. et al. Polymorphisms in complement genes and risk of preeclampsia in Taiyuan, China. Inflamm. Res. 65, 837–845 (2016). https://doi.org/10.1007/s00011-016-0968-4
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DOI: https://doi.org/10.1007/s00011-016-0968-4