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The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer

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Abstract

Introduction

Chronic inflammation is known to be mechanistically linked to the development of cancer. This article reviews and discusses the role of 15-lipoxygenase-1 (15-LOX-1) in the resolution of colitis and prevention of colitis-associated colorectal cancer.

Discussion

15-LOX-1 is an inducible and highly regulated enzyme in cells that play an important role in the production of lipid signaling mediators from linoleic acid and arachidonic acid. Together, these acids and 15-LOX-1 are the driving force for the resolution of acute and chronic inflammation in normal cells. Widespread inflammation can progress from local inflammation to ulcerative colitis, tumorigenesis, and finally invasive, metastatic, or benign colon cancer. Thus, reversing inflammation will halt the proliferation of cancerous cells. Decreased expression of 15-LOX-1 may lead to the development of colitis-associated colorectal cancer and colorectal cancer.

Conclusion

n-3 Polyunsaturated fatty acids are potent anti-inflammatory and pro-resolution products of 15-LOX-1 that can potentially prevent colitis-associated colorectal cancer and colorectal cancer.

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Acknowledgments

This study was funded by the Major Research Plan of the National Natural Science Foundation of China (Grant No. 91129718), China Postdoctoral Science Foundation (Grant no. 2015M571705), Jiangsu Province’s Outstanding Medical Academic Leader and Sci-tech Innovation Team Program (Grant no. LJ201117), Jiangsu Province’s Project of Scientific and Technological Innovation and Achievements Transformation (Grant no. BL2012055), the Natural Science Foundation of Jiangsu Province for high schools (Grant no. 10KJB310002), Jiangsu Province’s scientific and technological Supporting Program (Grant no. BE2010703), the Scientific Research Foundation of Jiangsu University (Grant no. 10JDG094).

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  1. School of Medicine, Jiangsu University, 301 Xuefu Road, Zhenjiang, 212013, Jiangsu, China

    Fei Mao, Mei Wang, Juanjuan Wang & Wen-Rong Xu

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  1. Fei Mao
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  2. Mei Wang
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  3. Juanjuan Wang
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  4. Wen-Rong Xu
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Correspondence to Fei Mao or Wen-Rong Xu.

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Mao, F., Wang, M., Wang, J. et al. The role of 15-LOX-1 in colitis and colitis-associated colorectal cancer. Inflamm. Res. 64, 661–669 (2015). https://doi.org/10.1007/s00011-015-0852-7

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  • DOI: https://doi.org/10.1007/s00011-015-0852-7

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