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H3 receptor renal expression in normal and diabetic rats

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Abstract

Introduction

To extend our previous observation of H4R upregulation in the kidney of diabetic rats, we evaluated in the same specimens the presence of the H3R.

Materials and methods

Kidney specimens from 24 8-week-old male Wistar rats (12 non-diabetic and 12 diabetic animals) were processed for both immunohistochemical and immunofluorescence analyses.

Results and conclusion

H3R is expressed in the apical membrane by collecting duct cells in the kidney of rats and it is significantly increased in diabetic animals. These data support the hypothesis that H3R could also mediate non-neuronal histamine effects, suggesting its involvement in fluid homeostasis.

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Acknowledgments

This work was supported by the Royal College of Anaesthesia/BJA, COST Action BM0806 (STSM hosted by the University of Durham) and the Ateneo/CSP2012 (H4 Histamine Receptor As A New Pharmacological Target For The Treatment Of Diabetic Nephropathy—HISDIAN) and Università degli Studi di Torino.

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Correspondence to Arianna Carolina Rosa.

Additional information

Responsible editor: John Di Battista.

A. Pini and P. L. Chazot are contributed equally to this work.

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Pini, A., Chazot, P.L., Veglia, E. et al. H3 receptor renal expression in normal and diabetic rats. Inflamm. Res. 64, 271–273 (2015). https://doi.org/10.1007/s00011-015-0808-y

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  • DOI: https://doi.org/10.1007/s00011-015-0808-y

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