Inflammation Research

, 58:727

The major inflammatory mediator interleukin-6 and obesity

  • Katalin Eder
  • Noemi Baffy
  • Andras Falus
  • Andras K. Fulop
Review

DOI: 10.1007/s00011-009-0060-4

Cite this article as:
Eder, K., Baffy, N., Falus, A. et al. Inflamm. Res. (2009) 58: 727. doi:10.1007/s00011-009-0060-4

Abstract

Adipose tissue is one of the main sources of inflammatory mediators, with interleukin-6 (IL-6) among them. Although high systemic levels of inflammatory mediators are cachectogenic and/or anorexic, today it is a widely propagated thesis that in the background of obesity, a low level of chronic inflammation can be found, with IL-6 being one of the many suggested mediators. This paper reviews the studies describing elevated IL-6 levels in obese patients and the role of adipocytes and adipose-tissue macrophages in the production of IL-6. The secretion of IL-6 is regulated by several physiologic or pathologic factors: hormones, cytokines, diet, physical activity, stress, hypoxia, and others. Adipose tissue-derived IL-6 may have an effect on metabolism through several mechanisms, including adipose tissue-specific gene expression, triglyceride release, lipoprotein lipase downregulation, insulin sensitivity, and so on. Having a better understanding of these mechanisms may contribute to the prevention and treatment of obesity.

Keywords

ObesityInterleukin-6Adipose tissueInflammationAdipokines

Copyright information

© Birkhäuser Verlag, Basel/Switzerland 2009

Authors and Affiliations

  • Katalin Eder
    • 1
  • Noemi Baffy
    • 2
  • Andras Falus
    • 1
    • 2
  • Andras K. Fulop
    • 2
  1. 1.Research Group for Inflammation Biology and ImmunogenomicsHungarian Academy of Sciences and Semmelweis UniversityBudapestHungary
  2. 2.Department of Genetics, Cell and ImmunobiologySemmelweis UniversityBudapestHungary