Article

Inflammation Research

, Volume 56, Issue 10, pp 402-408

Anti-inflammatory activity of quercetin and isoquercitrin in experimental murine allergic asthma

  • A. P. RogerioAffiliated withDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas
  • , A. KanashiroAffiliated withDepartamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo
  • , C. FontanariAffiliated withDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas
  • , E. V. G. da SilvaAffiliated withDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas
  • , Y. M. Lucisano-ValimAffiliated withDepartamento de Física e Química, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo
  • , E. G. SoaresAffiliated withDepartamento de Patologia, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo
  • , L. H. FaccioliAffiliated withDepartamento de Análises Clínicas, Toxicológicas e Bromatológicas Email author 

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Abstract.

Objective:

Eosinophils and cytokines are implicated in the pathogenesis of allergic diseases. In the present study, we investigate the anti-inflammatory effect of quercetin and isoquercitrin in a murine model of asthma.

Methods:

BALB/c mice were immunized (ovalbumin/aluminum hydroxide, s. c.), followed by two intranasal ovalbumin challenges. From day 18 to day 22 after the first immunization, the mice received daily gavages of isoquercitrin (15 mg/kg) or quercetin (10 mg/kg). Dexamethasone (1 mg/kg, s. c.) was administered as a positive control. Leucocytes were analyzed in bronchoalveolar lavage fluid (BALF), blood and pulmonary parenchyma at 24 h after the last ovalbumin challenge. Interleukin-5 (IL-5) was analyzed in BALF and lung homogenates.

Results:

In animals receiving isoquercitrin or quercetin, eosinophil counts were lower in the BALF, blood and lung parenchyma. Neutrophil counts in blood and IL-5 levels in lung homogenate were lower only in isoquercitrin-treated mice. No alterations in mononuclear cell numbers were observed.

Conclusion:

Quercetin and isoquercitrin are effective eosinophilic inflammation suppressors, suggesting a potential for treating allergies.

Keywords:

Quercetin Isoquercitrin Eosinophils Murine model of asthma