Skip to main content
SpringerLink
Log in

The diagnosis of secondary adrenal insufficiency: Low dose vs high dose ACTH stimulation test

  • Editorial
  • Published:
Journal of Endocrinological Investigation Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

References

  1. Hurel S.G., Thompson C.J., Watson M.J., Harris N.M., Baylis P.H., Kendall-Taylor P. The short synachten and insulin stress tests in the assessment of the hypothalamic-pituitary-adrenal axis. Clin. Endocrinol. 1996, 44: 141–146.

    Article  CAS  Google Scholar 

  2. Soule S., Fahie-Wilson M., Tomlinson S. Failure of the short ACTH test to unequivocally diagnose long-standing symptomatic secondary hypoadrenalism. Clin. Endocrinol. 1996, 44: 133–140.

    Article  Google Scholar 

  3. Streteen D.P.H., Anderson G.H. Jr, Bonaventura M.M. The potential for serious consequences from misinterpreting normal responses to the rapid adrenocorticotropin test. J. Clin. Endocrinol. Metab. 1996, 81: 285–290.

    Google Scholar 

  4. Tordjman K., Jaffe A., Grazas N., Apter C., Stern N. The role of low dose (1 mg) adrenocorticotropin test in the evaluation of patients with pituitary disease. J. Clin. Endocrinol. Metab. 1995, 80: 1301–1305.

    PubMed  CAS  Google Scholar 

  5. Abdu T.A.M., Elhadd T.A., Neary R., Clayton R.N. Comparison of the low-dose short Synachten test (1 mg), the conventional dose short Synachten test (250 mg), and the insulin tolerance test for the assessment of the hypothalamic-pituitary-adrenal axis in patients with pituitary disease. J. Clin. Endocrinol. Metab. 1999, 84: 838–843.

    PubMed  CAS  Google Scholar 

  6. Mayenknecht J., Diederich S., Bahr V., Plockinger U., Oelkers W. Comparison of low- and high-dose corticotropin stimulation tests in patients with pituitary disease. J. Clin. Endocrinol. Metab. 1998, 83: 1558–1562.

    Article  PubMed  CAS  Google Scholar 

  7. Weintrob N., Sprecher E., Josefsberg Z., et al. Standard and lowdose short adrenocorticotropin test compared with insulin induced hypoglycaemia for the assessment of the hypothalamicpituitary- adrenal axis in children with idiopathic multiple pituitary hormone deficiencies. J. Clin. Endocrinol. Metab. 1998, 83: 88–92.

    Article  PubMed  CAS  Google Scholar 

  8. Suliman A.M., Smith T.P., Labib M., Fiad T.M., Mckenna T.J. The low-dose ACTH test does not provide a useful assessment of the hypothalamic-pituitary-adrenal axis in secondary adrenal insufficiency. Clin. Endocrinol. 2002, 56: 533–539.

    Article  CAS  Google Scholar 

  9. Arvat E., Di Vito L., Lanfranco F., et al. Stimulatory effect of ACTH on cortisol, aldosterone and dehydroepiandrosterone secretion in normal humans: dose-response study. J. Clin. Endocrinol. Metab. 2000, 85: 3141–3146.

    PubMed  CAS  Google Scholar 

  10. Aimaretti G., Baffoni C., Di Vito L., et al. Hypopituitaric patients with corticotropin insufficiency show marked impairment of the cortisol response to ACTH 1-24 independently of the duration of the disease. J. Endocrinol. Invest. 2003, 26: 49–55.

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Molecular and Clinical Endocrinology and Oncology, “Federico II” University, Naples, Italy

    A. Colao & R. Pivonello

Authors
  1. A. Colao
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. R. Pivonello
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Colao, A., Pivonello, R. The diagnosis of secondary adrenal insufficiency: Low dose vs high dose ACTH stimulation test. J Endocrinol Invest 26, 1–2 (2003). https://doi.org/10.1007/BF03345114

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03345114

Search

Navigation