Pupil reaction to light in Alzheimer’s disease: evaluation of pupil size changes and mobility
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Aims: The aim of the study is to assess pupil size changes and mobility evaluation as a diagnostic marker in patients with probable Alzheimer’s disease (AD). Material and methods: Twenty-three control subjects and 23 patients with probable AD entered the study. The latter patients had been under observation for 2 years and had undergone all necessary examinations to verify their initial diagnosis. A full record of the pupil’s reaction to light was registered. Ten parameters from these data were measured, reported and then compared in both group of subjects. Results: Patients with probable AD had abnormal pupillary function compared with such function in healthy aging. All pupillary light reflex (PLR) variables differed significantly between the two groups (p<0.005) except baseline pupil diameter (D1) and minimum pupil diameter (D2). Maximum constriction acceleration (ACmax) was the best predictor in classifying a subject as normal or as AD with perfect classification ability (area under the curve =1, p<0.001). In addition, the correlation between the percentage recovery-redilatation (%D1) and ACmax was highly negative in the group of AD patients (r=−0.808, p<0.005). Conclusions: Pupil size changes and mobility examination may be a fast, non-invasive and efficient additional diagnostic marker in AD diagnosis.
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- Pupil reaction to light in Alzheimer’s disease: evaluation of pupil size changes and mobility
Aging Clinical and Experimental Research
Volume 19, Issue 5 , pp 364-371
- Cover Date
- Print ISSN
- Online ISSN
- Springer International Publishing
- Additional Links
- Alzheimer’s disease
- autonomic nervous system
- Author Affiliations
- 1. Laboratory of Clinical Neurophysiology, AHEPA Hospital, 1 Kyriakidi Street, 54636, Thessaloniki, Greece
- 2. Laboratory of Hygiene, USA
- 3. Second Department of Psychiatry, Medical School, Aristotle University of Thessaloniki, Thessaloniki, Greece
- 4. Department of Psychology, Saint Louis University, MO, USA