Aging Clinical and Experimental Research

, Volume 19, Issue 5, pp 364–371

Pupil reaction to light in Alzheimer’s disease: evaluation of pupil size changes and mobility


    • Laboratory of Clinical NeurophysiologyAHEPA Hospital
  • Catherine G. Brozou
    • Laboratory of Clinical NeurophysiologyAHEPA Hospital
  • Anna-Bettina Haidich
    • Laboratory of Hygiene
  • Dimitris Tsiptsios
    • Laboratory of Clinical NeurophysiologyAHEPA Hospital
  • Maria Nakou
    • Second Department of PsychiatryMedical School, Aristotle University of Thessaloniki
  • Anastasia Kabitsi
    • Department of PsychologySaint Louis University
  • Charalambos Giantselidis
    • Laboratory of Clinical NeurophysiologyAHEPA Hospital
  • Fotis Fotiou
    • Laboratory of Clinical NeurophysiologyAHEPA Hospital
Original Articles

DOI: 10.1007/BF03324716

Cite this article as:
Fotiou, D.F., Brozou, C.G., Haidich, A. et al. Aging Clin Exp Res (2007) 19: 364. doi:10.1007/BF03324716


Aims: The aim of the study is to assess pupil size changes and mobility evaluation as a diagnostic marker in patients with probable Alzheimer’s disease (AD). Material and methods: Twenty-three control subjects and 23 patients with probable AD entered the study. The latter patients had been under observation for 2 years and had undergone all necessary examinations to verify their initial diagnosis. A full record of the pupil’s reaction to light was registered. Ten parameters from these data were measured, reported and then compared in both group of subjects. Results: Patients with probable AD had abnormal pupillary function compared with such function in healthy aging. All pupillary light reflex (PLR) variables differed significantly between the two groups (p<0.005) except baseline pupil diameter (D1) and minimum pupil diameter (D2). Maximum constriction acceleration (ACmax) was the best predictor in classifying a subject as normal or as AD with perfect classification ability (area under the curve =1, p<0.001). In addition, the correlation between the percentage recovery-redilatation (%D1) and ACmax was highly negative in the group of AD patients (r=−0.808, p<0.005). Conclusions: Pupil size changes and mobility examination may be a fast, non-invasive and efficient additional diagnostic marker in AD diagnosis.


AcetylcholineAlzheimer’s diseaseautonomic nervous systemdementiapupillometry

Copyright information

© Springer Internal Publishing Switzerland 2007