Skip to main content
SpringerLink
Log in

A cure for cancer? Dealing with minimal residual disease

  • Perspective
  • Published:
Irish Journal of Medical Science Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Schlimok G, Funke I, Bock B, Schweiber B, Witte J, Riethmullcr G. 1990. Epithelial tumour cells in bone marrow of patients with colorectal cancer: immunocytochemical detection, phenotypic characterisation and prognostic significance.J Clin Oncol 8: 831–837.

    CAS  PubMed  Google Scholar 

  2. Lindemann F, Schlimok G, Dirshedl P, Witte J, Reithmuller G. 1992. Prognostic significance of mierometastatic tumour cells in bone marrow of colorectal cancer patients.Lancet 340: 685–689.

    Article  CAS  PubMed  Google Scholar 

  3. O’Sullivan GC, Collins JK, Kelly J, Morgan J, Madden M, Shanahan F. 1997. Micrometastases: marker of metastatic potential or evidence of residual disease. Gut 40: 512–515.

    PubMed  Google Scholar 

  4. O’Sullivan GC, Collins JK, O’Brien F, Crowley B, Murphy K, Lee G, Shanahan F. 1995. Micrometastases in bone marrow of patients undergoing ‘curative’ surgery for gastrointestinal cancer.Gastroenterology 109: 1535–1540.

    Article  PubMed  Google Scholar 

  5. Cote RJ, Rosen PP, Lesser ML, Old LJ, Osborne MP. 1991. Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases.J Clin Oncology 9: 1749–1756.

    CAS  Google Scholar 

  6. Braun S, Pantel K, Muller P et al. 2000. Cytokeratin positive cells in the bone marrow and survival of patients with Stage I, II or III Breast Cancer.N Engl J Med 342: 525–533.

    Article  CAS  PubMed  Google Scholar 

  7. Pantel K, Izbicki J, Passilick B, Angstwurm M, Haussinger K, Thetter O, Riethmuller G. 1996. Frequency and prognostic significance of micrometastatic tumour cells in bone marrow of patients with non-small-cell lung cancer without overt metastases.Lancet 347: 646–553.

    Article  Google Scholar 

  8. O’Sullivan G, Sheehan D, Clarke A, Stuart R, Kelly J, Kiely DM, Walsh T, Collins JK, Shanahan F. 1999. Micrometastases in esophagogastric cancer: High detection rate in resected rib segments.Gastroenterology 116: 543–548.

    Article  PubMed  Google Scholar 

  9. Uhr JW, Scheuermann RH, Street NE, Vitetta ES. 1997. Cancer dormancy: opportunities for new therapeutic approaches.Nature Medicine 3: 505–509.

    Article  CAS  PubMed  Google Scholar 

  10. Callaway MP, Briggs JC. The incidence of later recurrence (greater than 10 years): An analysis of 536 consecutive cases of cutaneous melanoma.Br J Plast Surg 1989; 42: 46–49.

    CAS  PubMed  Google Scholar 

  11. Henderson JC, Harris JR, Kinne DW, Hellman S. Cancer of the breast. In Cancer: Principles and Practice of Oncology, 3rd edn (eds DeVita VJ, Jr, Hellman S and Rosenberg SA) 1197–1268 (Lippincott, Philadelphia, 1989).

    Google Scholar 

  12. Mintz B, Illmensee K. Normal genetically mosaic mice produced from malignant terato-carcinoma cells. 1975; Proc Natl Acad Sci USA 72: 3585–3589.

    Article  CAS  PubMed  Google Scholar 

  13. Richards B, Zhang H, Phear G and Meuth M. Conditional imitator phenotypes in hMSH2-deficient tumour cell lines. 1997;Science 277: 1523–1526.

    Article  CAS  PubMed  Google Scholar 

  14. Penn I. 1993. The effect of immunosuppression on pre-existing cancers. Transplantation 55: 742–747.

    Article  CAS  PubMed  Google Scholar 

  15. Pardoll DM. 1998. Cancer vaccines.Nature Medicine 4: 525–531.

    Article  CAS  PubMed  Google Scholar 

  16. O’Connell J, Bennett MW, O’Sullivan GC, Collins JK, Shanahan, F. 1999. FAS counter-attack — the best form of defense?Nature Medicine 5: 267–268.

    Article  PubMed  Google Scholar 

  17. O’Mahony A, O’Sullivan GC, O’Connell J, Cotter TG, Collins JK. An immune suppressive factor derived from esophageal squamous carcinoma induces apoptosis in normal and transformed cells of lymphoid lineage.J Immunol 1993; 151: 4847–56.

    PubMed  Google Scholar 

  18. O’Sullivan GC, Corbett AR, Shanahan F, Collins JK. Regional immunosuppression in esophageal squamous cancer: Evidence from functional studies with matched lymph nodes.J Immunol 1996; 157: 4717–4720.

    PubMed  Google Scholar 

  19. Nagata S, Golstein P. The FAS death factor.Science 1995; 267: 1449–1456.

    Article  CAS  PubMed  Google Scholar 

  20. Folkman J. Antiangiogenic Therapy: In Cancer: Principles and Practice of Oncology, 5th edition edited by Vincent DeVita Jr, Samuel Hellman, Stephen A Rosenberg, Lippincott-Raven Publishers, Philadelphia 1997 Chapter 64, 3075–3085

    Google Scholar 

  21. Folkman J. Tumour angiogenesis. Therapeutic implications.N Engl Med 285: 1182–1186, 1971.

    Article  CAS  Google Scholar 

  22. Folkman J, Klagsburn M. Angiogcnic factors.Science 235: 442–447, 1987.

    Article  CAS  PubMed  Google Scholar 

  23. Holmgren L, O’Reilly MS, Folkman J. 1995. Dormancy of micrometastases: balanced proliferation and apoptosis in the presence of angiogenesis suppression.Nature Medicine 1: 149–153.

    Article  CAS  PubMed  Google Scholar 

  24. Bouck N. Angiogenesis: A mechanism by which oncogenes and tumour suppressor genes regulate tumorigenesis. Cancer Treat Res 63: 359–371, 1992.

    CAS  PubMed  Google Scholar 

  25. O’Reilly MS, Holmgren L, Shing Y, Chen C, Rosenthal RA, Moses M, Lane WS, Cao Y, Sage EH and Folkman J. Angiostatin: a novel angiogenesis inhibitor that mediates the suppression of metastases by a Lewis lung carcinoma. 1994; Cell 79: 315–328.

    Article  PubMed  Google Scholar 

  26. O’Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS, Flynn E, Birkhead JR, Olsen BR, Folkman J. 1997. Endostatin: an endogenous inhibitor of angiogenesis and tumour growth. Cell 88: 277–285.

    Article  PubMed  Google Scholar 

  27. O’Reilly MS, Holmgren L, Chen C, Folkman J. 1996. Angiostatin induces and sustains dormancy of human primary tumours in mice.Nature Medicine 2: 689–692.

    Article  PubMed  Google Scholar 

  28. McKenna HJ. 1999. Generating a T-cell immune response in vivo: can flt3-ligand-specific dendritic cells tip the balance? Cancer Immunology and Immunotherapy 48: 281–286.

    Article  CAS  PubMed  Google Scholar 

  29. Peron JP, Esche C, Subbotin VM, Maliszewski C, Lotze MT, Shurin MR. 1998. FLT3-Ligand administration inhibits liver metastases: Role of NK cells.J Immunol 161: 6164–6170.

    CAS  PubMed  Google Scholar 

  30. Levy R, Miller RA. Therapy of lymphoma directed at idiotypes. 1990;J Natl Cancer Inst Monqgr 10: 61–68.

    Google Scholar 

  31. Fendly BM et al. Characterisation of murine monoclonal antibodies reactive to either the human epidermal growth factor receptor or HER2/neu gene product. 1990; Cancer Res 50: 1550–1558.

    CAS  PubMed  Google Scholar 

  32. Drebin JA, Link VC, Greene MI. Monoclonal antibodies specific for the neu oncogene product directly mediate anti-tumour effects in vivo. 1988; Oncogene 2: 387–394.

    CAS  PubMed  Google Scholar 

  33. Riethmuller G et al. Randomised trial of monoclonal antibody for adjuvant therapy of resected Dukes’ C colorectal carcinoma. 1994;Lancet 3: 1172–1174.

    Google Scholar 

  34. McNamara DA, Harney JH, Walsh TN, Redmond HP, Bouchier-Hayes DJ. Significance of angiogenesis in cancer therapy.Br J Surg 1998 Oct 85(10) 1a49.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Surgery, Mercy Hospital, USA

    G. C. O’Sullivan

  2. Cork Cancer Research Centre, University College Cork, Ireland

    G. C. O’Sullivan

Authors
  1. G. C. O’Sullivan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

O’Sullivan, G.C. A cure for cancer? Dealing with minimal residual disease. Ir J Med Sci 169, 13–16 (2000). https://doi.org/10.1007/BF03170474

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF03170474

Keywords

Search

Navigation