Effect of acute starvation on monoamine oxidase and Na +, K +-ATPase activity in rat brain Authors
Received: 12 April 1990 Accepted: 07 August 1990 DOI:
Cite this article as: Kaur, G. & Kaur, K. Molecular and Chemical Neuropathology (1990) 13: 175. doi:10.1007/BF03159920 Abstract
The activities of monoamine oxidase (MAO), responsible for oxidative deamination of many biogenic amines, and Na
+, K +-ATPase, which plays a crucial role in the release mechanism of neurotransmitters, were determined in rat brain after acute starvation. They were assayed biochemically from four different regions of the brain in two subcellular fractions. Acute starvation decreased the activity of MAO, whereas the Na +, K +-ATPase activity was increased. An effect of starvation was also seen on the blood glucose level, body wt, and the protein content of different brain regions. Starvation or normal dietary fluctuations of certain nutrients that exert precursor influence over neurotransmitter synthesis are important to the brain, and contribute to its regulation of both neuroendocrine response and behavior. A rise in the substrate level, i.e., ATP, as a result of increased utilization of ketone bodies and low level of monoamines in the brain after acute starvation, may be the underlying factor for increasing the activity of Na +, K +-ATPase in rat brain. These results suggest that, probably, certain adaptive mechanisms become operative in the brain under disturbed physiological conditions. Index Entries Acute starvation neurotransmitter function nutrient availability monoamine oxidase activity diet fasting brain function brain neurochemical responses Na +, K +-ATPase References
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