Samenvatting
Delirium is a severe psychiatric syndrome that is highly prevalent in elderly patients in a general hospital. Primary prevention is important to prevent delirium. This article reviews recent developments with regard to multifactorial intervention trials for primary prevention of delirium. The review process involved a systematic search in MEDLINE, The Cochrane Database and CINAHL Database and subsequent examination of reference lists. Six studies were selected. Four studies showed that systemic interventions regarding medical-, nurse-led, environmental-, and educational items, were effective in preventing delirium. In one study a reduction was found in duration and severity of duration only. One study showed no effect on delirium at all. Despite the methodological weaknesses of the studies, conclusions are that different kinds of non-pharmacological interventions can be effective in preventing delirium.
Samenvatting
Delier is een ernstig psychiatrisch syndroom en kent een hoge prevalentie onder oudere patiëntenpopulaties in het ziekenhuis. Preventieve maatregelen zijn van belang ter voorkoming van een delier.
Dit overzicht schetst de waarde voor de praktijk van het beschikbare onderzoek naar multifactoriële interventies ter primaire preventie van delier. Informatie werd verzameld via zoekacties in MEDLINE, Cochrane Database en CINAHL Database en vervolgens via bestudering van relevante literatuurverwijzingen. Na toepassing van de selectiecriteria werden zes studies geselecteerd voor verdere bespreking. De resultaten laten zien dat in vier onderzoeken de systeeminterventies gericht op zowel medische-, verpleegkundige-, als omgeving- en educatieve factoren effectief blijken bij het voorkomen van delirium. Eén studie liet enkel effect zien op de duur en ernst van het delier en in één studie werd geen effect gevonden op preventie, duur en ernst van het delier. Ondanks methodologische tekortkomingen van de besproken onderzoeken is de conclusie dat verschillende soorten van niet-medicamenteuze interventies effectieve primaire preventie van delier mogelijk maken.
Literatuur
Galanakis P, Bickel H, Gradinger R, Von Gumppenberg S, Forstl H. Acute confusional state in the elderly following hip surgery: incidence, risk factors and complications. Int.J.Geriatr.Psychiatry 2001;16:349-55
Lindesay J, Rockwood K, Rolfson DB. The epidemiology of delirium. In: Lindesay J, Rockwood K, Macdonald AJ, editors. Delirium in old age. 1 ed. New York: Oxford University Press; 2002. p. 27-50.
Rockwood K. The occurrence and duration of symptoms in elderly patients with delirium. J Gerontol 1993;48:M162-M166.
Meagher DJ. Delirium: optimising management. BMJ 2001;322:144-49.
Keeffe , Lavan JN. Predicting delirium in elderly patients: development and validation of a risk-stratification model. Age Ageing 1996;25:317-21
Rowe JW. Geriatrics, prevention, and the remodeling of Medicare. N.Engl.J.Med. 1999;340:720-21
CBO. Multidisciplinaire richtlijn delirium. 2004. Ref Type: Report
Cole MG, Primeau F, McCusker J. Effectiveness of interventions to prevent delirium in hospitalized patients: a systematic review. CMAJ. 1996;155:1263-68.
Weber JB, Coverdale JH, Kunik ME. Delirium: current trends in prevention and treatment. Intern.Med.J. 2004;34:115-21.
American Psychiatric Association (APA). Diagnostic and statistical manual of mental disorders, third edition (DSM-III). Washington DC: American Psychiatric Association; 1980.
American Psychiatric Association (APA). Diagnostic and statistical manual of mental disorders, third edition revised (DSM-III-R). Washington DC: American Psychiatric Association; 1987.
American Psychiatric Association (APA). Diagnostic and statistical manual of mental disorders, fourth edition revised (DSM-IV). Washington DC: American Psychiatric Association; 1994.
Markowitz, A. M. Making Health Care Safer. 2004. Ref Type: Internet Communication
Guyatt GH, Haynes RB, Jaeschke RZ, Cook DJ, Green L, Naylor CD et al. Users' Guides to the Medical Literature: XXV. Evidence-based medicine: principles for applying the Users' Guides to patient care. Evidence-Based Medicine Working Group. JAMA 2000;284:1290-96.
Cole MG. Delirium: effectiveness of systematic interventions. Dement.Geriatr.Cogn Disord. 1999;10:406-11.
Inouye SK, Bogardus ST, Jr., Baker DI, Leo-Summers L, Cooney LM, Jr. The Hospital Elder Life Program: a model of care to prevent cognitive and functional decline in older hospitalized patients. Hospital Elder Life Program. J.Am.Geriatr.Soc. 2000;48:1697-706.
Inouye SK. Prevention of delirium in hospitalized older patients: risk factors and targeted intervention strategies. Ann.Med. 2000;32:257-63.
Inouye SK, Bogardus ST, Jr., Williams CS, Leo-Summers L, Agostini JV. The role of adherence on the effectiveness of nonpharmacologic interventions: evidence from the delirium prevention trial. Arch.Intern.Med. 2003;163:958-64.
Rizzo JA, Bogardus ST, Jr., Leo-Summers L, Williams CS, Acampora D, Inouye SK. Multicomponent targeted intervention to prevent delirium in hospitalized older patients: what is the economic value? Med.Care 2001;39:740-52.
Bogardus ST, Jr., Desai MM, Williams CS, Leo-Summers L, Acampora D, Inouye SK. The effects of a targeted multicomponent delirium intervention on postdischarge outcomes for hospitalized older adults. Am.J.Med. 2003;114:383-90.
Cole MG, McCusker J, Bellavance F, Primeau FJ, Bailey RF, Bonnycastle MJ et al. Systematic detection and multidisciplinary care of delirium in older medical inpatients: a randomized trial. CMAJ. 2002;167:753-59.
Owens JF, Hutelmyer CM. The effect of preoperative intervention on delirium in cardiac surgical patients. Nurs.Res. 1982;31:60-62.
Nagley SJ. Predicting and preventing confusion in your patients. J.Gerontol.Nurs. 1986;12:27-31.
Williams MA, Campbell EB, Raynor WJ, Mlynarczyk SM, Ward SE. Reducing acute confusional states in elderly patients with hip fractures. Res Nurs Health 1985;8:329-37.
Marcantonio ER, Flacker JM, Wright RJ, Resnick NM. Reducing delirium after hip fracture: a randomized trial. J.Am.Geriatr.Soc. 2001;49:516-22.
Gustafson Y, Brannstrom B, Berggren D, Ragnarsson JI, Sigaard J, Bucht G et al. A geriatric-anesthesiologic program to reduce acute confusional states in elderly patients treated for femoral neck fractures. J.Am.Geriatr.Soc. 1991;39:655-62.
Inouye SK, Bogardus ST, Jr., Charpentier PA, Leo-Summers L, Acampora D, Holford TR et al. A multicomponent intervention to prevent delirium in hospitalized older patients. N.Engl.J.Med. 1999;340:669-76.
Lundstrom M, Edlund A, Lundstrom G, Gustafson Y. Reorganization of nursing and medical care to reduce the incidence of postoperative delirium and improve rehabilitation outcome in elderly patients treated for femoral neck fractures. Scand.J.Caring.Sci. 1999;13:193-200.
Milisen K, Foreman MD, Abraham IL, De Geest S, Godderis J, Vandermeulen E et al. A nurse-led interdisciplinary intervention program for delirium in elderly hip-fracture patients. J.Am.Geriatr.Soc. 2001;49:523-32.
Wanich CK, Sullivan-Marx EM, Gottlieb GL, Johnson JC. Functional status outcomes of a nursing intervention in hospitalised elderly. Image 1992;24:201-07.
Inouye SK, van Dyck CH, Alessi CA, Balkin S, Siegal AP, Horwitz RI. Clarifying confusion: the confusion assessment method. A new method for detection of delirium. Ann.Intern.Med. 1990;113:941-48.
Albert MS, Levkoff SE, Reilly C, Liptzin B, Pilgrim D, Cleary PD et al. The delirium symptom interview: an interview for the detection of delirium symptoms in hospitalized patients. J Geriatr.Psychiatry Neurol. 1992;5:14-21.
Breitbart W, Rosenfeld B, Roth A, Smith MJ, Cohen K, Passik S. The Memorial Delirium Assessment Scale. J Pain Symptom.Manage. 1997;13:128-37.
Laurila JV, Pitkala KH, Strandberg TE, Tilvis RS. Impact of different diagnostic criteria on prognosis of delirium: a prospective study. Dement.Geriatr.Cogn Disord. 2004;18:240-44.
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klinisch geriater, Medisch Centrum Alkmaar, afdeling Klinische Geriatrie
verpleegkundig specialist Geriatrie en verplegingswetenschapper
neuropsycholoog, Medisch Centrum Alkmaar, afdeling Klinische Geriatrie
hoogleraar, docent Verplegingswetenschap, Centrum voor Ziekenhuis- en Verplegingswetenschap, Katholieke Universiteit Leuven en Verpleegkundig Specialist, dienst Geriatrie, Universitaire Ziekenhuizen Leuven
Correspondentie Kees Kalisvaart, Medisch Centrum Alkmaar, Afdeling Geriatrie (170), Postbus 501, 1800 AM Alkmaar, Tel: +31-72-5482380.
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Kalisvaart, C.J., Vreeswijk, R., de Jonghe, J.F.M. et al. Een systematisch overzicht van multifactoriële interventies ter primaire preventie van delier bij ouderen. GEEG 36, 244–250 (2005). https://doi.org/10.1007/BF03074747
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DOI: https://doi.org/10.1007/BF03074747