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Synthesis of the lactone of 2-carboxy-4-hydroxy-7-methoxy-1, 2, 3, 4-tetrahydrophenanthrone

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Summary

Starting from 6-methoxynaphthaldehyde-2, 2-carboxy-7-methoxy-1, 2, 3, 4-tetrahydrophenanthrone-4 was prepared. Sodium borohydride reduction of the keto-acid followed by chromic acid oxidation yielded the lactone of 2-carboxy-4-hydroxy-7-methoxy-1, 2, 3, 4-tetrahydrophenanthrone. Alkylation of the lactone of 2-carboxy-4-hydroxy-6-methoxytetralone was not promising.

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Authors and Affiliations

  1. Organic Chemistry Department, Indian Institute of Science, Bangalore-12

    D. K. Banerjee F.A.Sc. & G. Bagavant

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  1. D. K. Banerjee F.A.Sc.
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  2. G. Bagavant
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Banerjee, D.K., Bagavant, G. Synthesis of the lactone of 2-carboxy-4-hydroxy-7-methoxy-1, 2, 3, 4-tetrahydrophenanthrone. Proc. Indian Acad. Sci. 53, 113–122 (1961). https://doi.org/10.1007/BF03045798

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