Synthesis of the lactone of 2-carboxy-4-hydroxy-7-methoxy-1, 2, 3, 4-tetrahydrophenanthrone

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access

Summary

Starting from 6-methoxynaphthaldehyde-2, 2-carboxy-7-methoxy-1, 2, 3, 4-tetrahydrophenanthrone-4 was prepared. Sodium borohydride reduction of the keto-acid followed by chromic acid oxidation yielded the lactone of 2-carboxy-4-hydroxy-7-methoxy-1, 2, 3, 4-tetrahydrophenanthrone. Alkylation of the lactone of 2-carboxy-4-hydroxy-6-methoxytetralone was not promising.