Review

Annals of Nuclear Medicine

, Volume 19, Issue 2, pp 65-74

Human cerebral circulation: positron emission tomography studies

  • Hiroshi ItoAffiliated withDepartment of Nuclear Medicine and Radiology, Division of Brain Sciences, Institute of Development, Aging and Cancer Tohoku UniversityDepartment of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels
  • , Iwao KannoAffiliated withDepartment of Radiology and Nuclear Medicine, Akita Research Institute of Brain and Blood Vessels
  • , Hiroshi FukudaAffiliated withDepartment of Nuclear Medicine and Radiology, Division of Brain Sciences, Institute of Development, Aging and Cancer Tohoku University Email author 

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Abstract

We reviewed the literature on human cerebral circulation and oxygen metabolism, as measured by positron emission tomography (PET), with respect to normal values and of regulation of cerebral circulation. A multicenter study in Japan showed that between-center variations in cerebral blood flow (CBF), cerebral blood volume (CBV), cerebral oxygen extraction fraction (OEF) and cerebral metabolic rate of oxygen (CMRO2) values were not considerably larger than the corresponding within-center variations. Overall mean ± SD values in cerebral cortical regions of normal human subjects were as follows: CBF = 44.4 ± 6.5 m//100 m//min; CBV = 3.8 ± 0.7 m//100ml; OEF = 0.44 ± 0.06; CMRO2 = 3.3 ± 0.5 m//100 m//min (11 PET centers, 70 subjects). Intrinsic regulation of cerebral circulation involves several factors. Autoregulation maintains CBF in response to changes in cerebral perfusion pressure; chemical factors such as PaCO2 affect cerebral vascular tone and alter CBF; changes in neural activity cause changes in cerebral energy metabolism and CBF; neurogenic control of CBF occurs by sympathetic innervation. Regional differences in vascular response to changes in PaCO2 have been reported, indicating regional differences in cerebral vascular tone. Relations between CBF and CBV during changes in PaCO2 and during changes in neural activity were in good agreement with Poiseuille’s law. The mechanisms of vascular response to neural activation and deactivation were independent on those of responses to PaCO2 changes. CBV in a brain region is the sum of three components: arterial, capillary and venous blood volumes. It has been reported that the arterial blood volume fraction is approximately 30% in humans and that changes in human CBV during changes in PaCO2 are caused by changes in arterial blood volume without changes in venous blood volume. These findings should be considered in future studies of the pathophysiology of cerebrovascular diseases.

Key words

cerebral circulation PET autoregulation PaCO2 neural activity