Breast Cancer

, Volume 3, Issue 2, pp 131–134

Cystic hypersecretory duct carcinoma of the breast: A case report describing the cytologic features


  • Takuya Moriya
    • Department of PathologyKawasaki Hospital, Kawasaki Medical School
  • Jishu Ito
    • Department of PathologyKawasaki Hospital, Kawasaki Medical School
  • Hirohisa Takasuga
    • Department of PathologyKawasaki Hospital, Kawasaki Medical School
  • Kunjyasu Okazaki
    • Kunitomi Clinic
Case Report

DOI: 10.1007/BF02966974

Cite this article as:
Moriya, T., Ito, J., Takasuga, H. et al. Breast Cancer (1996) 3: 131. doi:10.1007/BF02966974


We report the clinical, cytological and pathological features of so-called cystic hypersecretory duct carcinoma occurring in a 60-year-old Japanese woman. The tumor manifested a multicystic mass ultrasonographically, and aspiration biopsy cytology revealed atypical ductal epithelial cells with vacuolar cytoplasm. A modified radical mastectomy was performed. Histologically, the lesion was characterized by many dilated ducts containing eosinophilic secretions, which resembled thyroid colloid. The ducts were lined by an intraductal micropapillary carcinoma with hobnail-shaped cells, and were positive for lactalbumin immunohistochemically. Additionally, a so-called cystic hypersecretory hyperplasia was seen in the surrounding breast parenchyma. Although a direct transition from the hyperplasia to the carcinoma was not proved, a close relationship between the two lesions was suggested.

Key words




Cystic hypersecretory duct carcinoma


Cystic hypersecretory hyperplasia

Copyright information

© The Japanese Breast Cancer Society 1996