Case Report

Breast Cancer

, Volume 3, Issue 2, pp 131-134

Cystic hypersecretory duct carcinoma of the breast: A case report describing the cytologic features

  • Takuya MoriyaAffiliated withDepartment of Pathology, Kawasaki Hospital, Kawasaki Medical School
  • , Jishu ItoAffiliated withDepartment of Pathology, Kawasaki Hospital, Kawasaki Medical School
  • , Hirohisa TakasugaAffiliated withDepartment of Pathology, Kawasaki Hospital, Kawasaki Medical School
  • , Kunjyasu OkazakiAffiliated withKunitomi Clinic

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Abstract

We report the clinical, cytological and pathological features of so-called cystic hypersecretory duct carcinoma occurring in a 60-year-old Japanese woman. The tumor manifested a multicystic mass ultrasonographically, and aspiration biopsy cytology revealed atypical ductal epithelial cells with vacuolar cytoplasm. A modified radical mastectomy was performed. Histologically, the lesion was characterized by many dilated ducts containing eosinophilic secretions, which resembled thyroid colloid. The ducts were lined by an intraductal micropapillary carcinoma with hobnail-shaped cells, and were positive for lactalbumin immunohistochemically. Additionally, a so-called cystic hypersecretory hyperplasia was seen in the surrounding breast parenchyma. Although a direct transition from the hyperplasia to the carcinoma was not proved, a close relationship between the two lesions was suggested.

Key words

Breast Carcinoma Pathology Cytology Ultrasonography