Skip to main content
SpringerLink
Log in

Oxygen usage of the cat carotid body perfused with cell-free solutions

  • Published:
Irish Journal of Medical Science Aims and scope Submit manuscript

Summary

Carotid bodies of cats were perfused with saline solutions and their oxygen usages (\(\dot Vo_2 \)) calculated using the Fick equation. In the initial stages of perfusion, the values of\(\dot Vo_2 \) were similar to those reported for blood perfused carotid bodies. As perfusion continued, carotid body\(\dot Vo_2 \) decreased sharply and these decreases were not prevented by adding plasma to the perfusates. Blood perfusion in the interval between cell-free perfusion periods stimulated\(\dot Vo_2 \). It is concluded that the process of cell-free perfusion is unable to maintain the high levels of oxidative metabolism associated with blood perfused carotid bodies.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Similar content being viewed by others

References

  • Acker, H. and Lübbers, D. W. 1975. The meaning of the tissue Po2 of the carotid body for the chemoreceptive process,in The Peripheral Arterial Chemoreceptors. Ed. by M. J. Purves. Cambridge University Press. p. 325.

  • Acker, H. and Lübbers, D. W. 1976. Oxygen transport capacity of the capillary blood within the carotid body. Pflügers Arch. 366, 241.

    Article  PubMed  CAS  Google Scholar 

  • Acker, H. and Lübbers, D. W. 1977. The kinetics of local tissue Po2 decrease after perfusion stop within the carotid body of the cat in vivo and in vitro. Pllügers Arch. 369, 135.

    Article  CAS  Google Scholar 

  • Acker, H., Weigelt, H., Lübbers, D. W., Bingmann, D. and Caspers, H. 1976. Effect of changes in Ca++ and K+ activity upon tissue Po2 and chemoreceptor activity of the cat carotid body,in Morphology and Mechanisms of Chemoreceptors. Ed. by A. S. Paintal Delhi. Vallabhbhai Patel Chest Institute. p. 103.

    Google Scholar 

  • Daly, M. de B., Lambertsen, C. J. and Schweitzer, A. 1954. Observations on the volume of blood flow and oxygen utilization of the carotid body in the cat. J. Physiol. 125, 67.

    Google Scholar 

  • Dixon, M. 1951. Manometric methods. 3rd Ed. Cambridge Univeritty Press. p. 52.

  • Eyzaguirre, C. and Zapata, P. 1968. Pharmacology of pH effects on carotid body chemoreceptors in vitro. J. Physiol. 195, 557.

    PubMed  CAS  Google Scholar 

  • Fay, F. S. 1970. Oxygen consumption of the carotid body. Am. J. Physiol. 218, 518.

    PubMed  CAS  Google Scholar 

  • Joels, N., Neil, E. and Vaughan Hudson, B. 1961. The investigation of chemoreceptor responses from the perfused carotid body in the cat. J. Physiol. 155, 30p.

  • Joels, N. and Neil, E. 1968. The idea of a sensory transmitter,in Arterial Chemoreceptors. Ed. by R. W. Torrance. Oxford. Blackwell. p. 153.

    Google Scholar 

  • Leitner, L. M. and Liaubet, M. J. 1971. Carotid body oxygen consumption of the cat in vitro. Pflügers Arch. 323, 315.

    Article  PubMed  CAS  Google Scholar 

  • Mills, E. and Jöbsis, F. F. 1972. Mitochondrial respiratory chain of carotid body and chemoreceptor response to changes in oxygen tension. J. Neurophysiol. 35, 405.

    PubMed  CAS  Google Scholar 

  • Neil, E. and O'Regan, R. G. 1971. The effects of electrical stimulation of the distal end of the cut sinus and aortic nerves on peripheral arterial chemoreceptor activity in the cat. J. Physiol. 215, 15.

    PubMed  CAS  Google Scholar 

  • O'Regan, R. G. 1974. Oxygen usage of the salineperfused carotid body of the cat. Irish J. Med. Sci. 143, 362.

    Google Scholar 

  • O'Regan, R. G. 1979. Responses of the chemoreceptors of the cat carotid body perfused with cell-free solutions. Irish J. Med. Sci. 143, 78.

    Article  Google Scholar 

  • Purves, M. J. The effect of hypoxia, hypercapnia and hypotension upon carotid body blood flow and oxygen consumption in the cat. J. Physiol. 209, 395.

  • Seidl, Ellen. 1976. On the variability of form and vascularization of the cat carotid body. Anat. Embryol. 149, 79.

    Article  PubMed  CAS  Google Scholar 

  • Starlinger, H. and Lübbers, D. W. 1976. Oxygen consumption of the isolated carotid body tissue (cat). Pflügers Arch. 366, 61.

    Article  PubMed  CAS  Google Scholar 

  • Whalen, W. J. and Nair, P. 1976. Po2 in the carotid body perfused and/or superfused with cell-free media. J. Appl. Physiol. 41, 180.

    PubMed  CAS  Google Scholar 

  • Whalen, W. J. and Nair, P. 1977. Factors affecting O2 consumption of the cat carotid body,in Chemoreception in the Carotid Body. Ed by H. Acker, S. Fidone, D. Pallot C. Eyzaguirre, D. W. Lübbers, R. W. Torrance. Springer-Verlag. Berlin. p. 233.

    Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Physiology, University College, Earlsfort Terrace, Dublin 2

    R. G. O'Regan

Authors
  1. R. G. O'Regan
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

O'Regan, R.G. Oxygen usage of the cat carotid body perfused with cell-free solutions. I.J.M.S. 148, 69–77 (1979). https://doi.org/10.1007/BF02938055

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02938055

Keywords

Search

Navigation