Review Article

Journal of Genetics

, Volume 75, Issue 2, pp 181-192

First online:

Mismatch repair genes of eukaryotes

  • R. Geeta VaniAffiliated withDepartment of Biochemistry, Indian Institute of Science
  • , M. R. S. RaoAffiliated withDepartment of Biochemistry, Indian Institute of Science

Rent the article at a discount

Rent now

* Final gross prices may vary according to local VAT.

Get Access


Mismatches that arise during replication or genetic recombination or owing to damage to DNA by chemical agents are recognized by mismatch repair systems. The pathway has been characterized in detail inEscherichia coll. Several homologues of the genes encoding the proteins of this pathway have been identified in the yeastSaccharomyces cerevisiae and in human cells. Mutations in the human geneshMSH2, hMLH1, hPMS1 andhPMS2 have been linked to hereditary nonpolyposis colon cancer (HNPCC) and to some sporadic tumours. Mismatch repair also plays an antirecombinogenic role and is implicated in speciation.


Mismatch repair eukaryotes cancer