Journal of Genetics

, Volume 75, Issue 2, pp 181–192

Mismatch repair genes of eukaryotes

Authors

  • R. Geeta Vani
    • Department of BiochemistryIndian Institute of Science
  • M. R. S. Rao
    • Department of BiochemistryIndian Institute of Science
Review Article

DOI: 10.1007/BF02931761

Cite this article as:
Geeta Vani, R. & Rao, M.R.S. J. Genet. (1996) 75: 181. doi:10.1007/BF02931761

Abstract

Mismatches that arise during replication or genetic recombination or owing to damage to DNA by chemical agents are recognized by mismatch repair systems. The pathway has been characterized in detail inEscherichia coll. Several homologues of the genes encoding the proteins of this pathway have been identified in the yeastSaccharomyces cerevisiae and in human cells. Mutations in the human geneshMSH2, hMLH1, hPMS1 andhPMS2 have been linked to hereditary nonpolyposis colon cancer (HNPCC) and to some sporadic tumours. Mismatch repair also plays an antirecombinogenic role and is implicated in speciation.

Keywords

Mismatch repair eukaryotes cancer

Copyright information

© Indian Academy of Sciences 1996