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Cyclosporin a inhibits the release of histamine and peptide leukotriene C4 from human lung mast cells

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Ricerca in clinica e in laboratorio

Summary

We investigated the effect of cyclosporin A (CsA) onin vitro release of chemical mediators from mast cells purified from human lung tissues. CsA (3 x 10-2 to 1 μg/ml) dose-dependently inhibited IgE-mediated release of histamine and peptide leukotriene C4 (LTC4) from human lung mast cells. The same concentrations of CsA also inhibited the release of histamine from lung mast cells challenged with the Ca2+ ionophore A23187. Therefore, CsA in pharmacological concentrations inhibits the IgE- and non-IgE-mediated release of inflammatory mediators from mast cells purified from human lung tissues.

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This work was supported by grants from theConsiglio Nazionale delle Ricerche (CNR) (contracts n2 85.00491.04 and 86.00088.04),the Ministero della Pubblica Istruzione and theMinistero della Sanità, Roma, Italy.

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Marone, G., Triggiani, M., Cirillo, R. et al. Cyclosporin a inhibits the release of histamine and peptide leukotriene C4 from human lung mast cells. La Ricerca Clin. Lab. 18, 53–59 (1988). https://doi.org/10.1007/BF02918819

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