References
Prasad, A.S.: Clinical, biochemical and pharmacological role of zinc. Annu. Rev. Pharmacol. Toxicol.20: 393 (1979).
Hambidge, K.M.: Zinc deficiency in man: its origins and effects. Phil. Trans. R. Soc.B294: 129 (1981).
Prasad, A.S.; Sandstead, H.H.; Schulert, A.R.; Miale, A.; Fand, Z.: Zinc and iron deficiencies in male subjects with dwarfism and hypogonadism but without ancyclostomiasis, schistosomiasis or severe anemia. Am. J. clin. Nutr.12: 437 (1963).
Fraker, P.J.; Haas, S.M.; Luecke, R.W.: Effect of zinc deficiency on the immune response of the young adult A/J mouse. J. Nutr.107: 1889 (1977).
Fraker, P.J.; DePasquale-Jardieu, P.; Zwickl, C.M.; Leucke, R.W.: Regeneration of T-cell helper function in zinc-deficient adult mice. Proc. natn. Acad. Sci. USA75: 5660 (1978).
Zwickl, C.W.; Fraker, P.J.: Restoration of the antibody mediated response of zinc/caloric deficient neonatal mice. Immunol. Commun,9: 611 (1980).
DePasquale-Jardieu, P.; Fraker, P.J.: Altered B-cell responses induced by a trace element deficiency. Fed. Proc.41: 218 (1982).
Leucke, R.W.; Simonel, C.E.; Fraker, P.J.: The effect of restricted dietary intake on the antibody mediated response of the zinc deficient A/J mouse. J. Nutr.108: 881 (1978).
Fraker, P.J.; Zwickl, C.M.; Luecke, R.W.: Delayed type hypersensitivity in zinc deficient adult mice: impairment and restoration of responsivity to dinitrofluorobenzene. J. Nutr.112: 309 (1982).
Oleske, J.M.; Westphal, M.L.; Shore, S.; Gorden, D.; Bogden, J.D.; Nahmias, A.: Zinc therapy of depressed cellular immunity in acrodermatitis enteropathica. Am. J. Dis. Child133: 915 (1979).
Pekarek, R.S.; Sandstead, H.H.; Jacob, R.A.; Barcome, D.F.: Abnormal cellular immune responses during acquired zinc deficiency. Am. J. clin. Nutr.32: 1466 (1979).
Fernandes, G.; Nair, M.; Onoe, K.; Tanaka, T.; Floyd, R.; Good, R.; Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice. Proc. natn. Acad. Sci. USA76: 457 (1979).
Chandra, R.K.: Single nutrient deficiency and cell-mediated immune responses. Am. J. clin. Nutr.33: 736 (1980).
Frost, P.; Rabbani, P.; Smith, J.; Prasad, A.: Cell-mediated cytotoxicity and tumor growth in zinc-deficient mice. Proc. Soc. exp. Biol. Med.167: 333 (1981).
Nash, L.; Iwata, T.; Fernandes, G.; Good, R.A.; Incefy, G.: Effect of zinc deficiency on autologous rosette-forming cells. Cell Immunol.48: 238 (1979).
Hurley, L.S.: The roles of trace elements in foetal and neonatal development. Phil. Trans. R. Soc.B294: 145 (1981).
Hildebrandt, K.J.; Luecke, R.W.; Fraker, P.J.: Effect of maternal dietary zinc on growth and mitogenic responsiveness in suckling mice. Fed. Proc.41: 84 (1982).
DePasquale-Jardieu, P.; Fraker, P.J.: The role of corticosterone in the loss of immune function in the zinc-deficient A/J mouse. J. Nutr.109: 1847 (1979).
DePasquale-Jardieu, P.; Fraker, P.J.: Further characterization of the role of corticosterone in the loss of humoral immunity in zinc-deficient A/J mice as determined by adrenalectomy. J. Immun.124: 2650 (1980).
Falchuk, K.H.; Hardy, C.; Ulpino, L.; Vallee, B.: RNA metabolism, manganese, and RNA polymerases of zinc-sufficient and zinc-deficient Euglena gracilis. Proc. natn. Acad. Sci. USA75: 4175 (1978).
Dardenne, M.; Pleau, J.; Lefrancier, P.; Bach, J.F.: Rôle du zinc et d’autres métaux dans l’activité biologique du FTS (thymuline). C. hebd. Séanc. Acad. Sci., Paris292: 793 (1981).
Iwata, T.; Incefy, G.S.; Tanaka, T.; Fernandes, G.; Menendez-Botet, C.J.; Pih, K.; Good, R.A.: Circulating thymic hormone levels in zinc deficiency. Cell Immunol.47: 100 (1979).
Chandra, R.K.; Heresi, G.; Au, B.: Serum thymic factor activity in deficiencies of calories, zinc, vitamin A and pyridoxine. Clin. exp. Immunol.42: 332 (1980).
Chvapil, M.; Stankova, L.; Bernhard, D.; Weldy, P.; Carlson, E.; Campbell, J.: Effect of zinc on peritoneal macrophages in vitro. Infect. Immunity16: 307 (1977).
Ruhl, H.; Kirchner, H.; Bochert, G.: Kinetics of the Zn2+ - stimulation of human peripheral lymphocytes in vitro. Proc. Soc. exp. Biol. Med.137: 1089 (1971).
Berger, N.A.; Skinner, A.M.: Characterization of lymphocyte transformations by zinc ions. J. Cell Biol.61: 45 (1974).
Hart, D.: Effect of zinc chloride on hamster lymphoid cells: mitogenicity and differential enhancement of lipopolysaccharide stimulation of lymphocytes. Infect. Immunity19: 457 (1978).
Duchateau, J.; Delespesse, G.; Vereeke, P.: Influence of oral zinc supplementation on the lymphocyte response to mitogens of normal subjects. Am. J. clin. Nutr.34: 88 (1981).
Golden, M.H.; Golden, B.E.; Harland, P.S.; Jackson, A.A.: Zinc and immunocompetence in protein-energy malnutrition. Lancetii: 1226 (1978).
Cunningham-Rundles, C.; Cunningham-Rundles, S.; Iwata, T.; Incefy, G.; Garofalo, J.A.; Menendez-Botet, C.; Lewis, V.; Twomey, J.J.; Good, R.A.: Zinc deficiency, depressed thymic hormones and T lymphocyte dysfunction in patients with hypogamma globulinemia. Clin. Immunol. Immunopathol.21: 387 (1981).
Beach, R.S.; Gershwin, M.E.; Hurley, L.S.: Nutritional factors and autoimmunity: immunopathology of zinc deprivation in New Zealand mice. J. Immun.126: 1999 (1981).
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raker, P.J.F. Zinc deficiency: A common immunodeficiency state. Surv. immunol. Res. 2, 155–163 (1983). https://doi.org/10.1007/BF02918575
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DOI: https://doi.org/10.1007/BF02918575