Skip to main content
Log in

Zinc deficiency: A common immunodeficiency state

  • Clinical immunology reviews
  • Published:
Survey of Immunologic Research Aims and scope Submit manuscript

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

References

  1. Prasad, A.S.: Clinical, biochemical and pharmacological role of zinc. Annu. Rev. Pharmacol. Toxicol.20: 393 (1979).

    Article  Google Scholar 

  2. Hambidge, K.M.: Zinc deficiency in man: its origins and effects. Phil. Trans. R. Soc.B294: 129 (1981).

    Article  Google Scholar 

  3. Prasad, A.S.; Sandstead, H.H.; Schulert, A.R.; Miale, A.; Fand, Z.: Zinc and iron deficiencies in male subjects with dwarfism and hypogonadism but without ancyclostomiasis, schistosomiasis or severe anemia. Am. J. clin. Nutr.12: 437 (1963).

    CAS  PubMed  Google Scholar 

  4. Fraker, P.J.; Haas, S.M.; Luecke, R.W.: Effect of zinc deficiency on the immune response of the young adult A/J mouse. J. Nutr.107: 1889 (1977).

    CAS  PubMed  Google Scholar 

  5. Fraker, P.J.; DePasquale-Jardieu, P.; Zwickl, C.M.; Leucke, R.W.: Regeneration of T-cell helper function in zinc-deficient adult mice. Proc. natn. Acad. Sci. USA75: 5660 (1978).

    Article  CAS  Google Scholar 

  6. Zwickl, C.W.; Fraker, P.J.: Restoration of the antibody mediated response of zinc/caloric deficient neonatal mice. Immunol. Commun,9: 611 (1980).

    CAS  PubMed  Google Scholar 

  7. DePasquale-Jardieu, P.; Fraker, P.J.: Altered B-cell responses induced by a trace element deficiency. Fed. Proc.41: 218 (1982).

    Google Scholar 

  8. Leucke, R.W.; Simonel, C.E.; Fraker, P.J.: The effect of restricted dietary intake on the antibody mediated response of the zinc deficient A/J mouse. J. Nutr.108: 881 (1978).

    Google Scholar 

  9. Fraker, P.J.; Zwickl, C.M.; Luecke, R.W.: Delayed type hypersensitivity in zinc deficient adult mice: impairment and restoration of responsivity to dinitrofluorobenzene. J. Nutr.112: 309 (1982).

    CAS  PubMed  Google Scholar 

  10. Oleske, J.M.; Westphal, M.L.; Shore, S.; Gorden, D.; Bogden, J.D.; Nahmias, A.: Zinc therapy of depressed cellular immunity in acrodermatitis enteropathica. Am. J. Dis. Child133: 915 (1979).

    Article  CAS  PubMed  Google Scholar 

  11. Pekarek, R.S.; Sandstead, H.H.; Jacob, R.A.; Barcome, D.F.: Abnormal cellular immune responses during acquired zinc deficiency. Am. J. clin. Nutr.32: 1466 (1979).

    CAS  PubMed  Google Scholar 

  12. Fernandes, G.; Nair, M.; Onoe, K.; Tanaka, T.; Floyd, R.; Good, R.; Impairment of cell-mediated immunity functions by dietary zinc deficiency in mice. Proc. natn. Acad. Sci. USA76: 457 (1979).

    Article  CAS  Google Scholar 

  13. Chandra, R.K.: Single nutrient deficiency and cell-mediated immune responses. Am. J. clin. Nutr.33: 736 (1980).

    CAS  PubMed  Google Scholar 

  14. Frost, P.; Rabbani, P.; Smith, J.; Prasad, A.: Cell-mediated cytotoxicity and tumor growth in zinc-deficient mice. Proc. Soc. exp. Biol. Med.167: 333 (1981).

    Article  CAS  PubMed  Google Scholar 

  15. Nash, L.; Iwata, T.; Fernandes, G.; Good, R.A.; Incefy, G.: Effect of zinc deficiency on autologous rosette-forming cells. Cell Immunol.48: 238 (1979).

    Article  CAS  PubMed  Google Scholar 

  16. Hurley, L.S.: The roles of trace elements in foetal and neonatal development. Phil. Trans. R. Soc.B294: 145 (1981).

    Article  Google Scholar 

  17. Hildebrandt, K.J.; Luecke, R.W.; Fraker, P.J.: Effect of maternal dietary zinc on growth and mitogenic responsiveness in suckling mice. Fed. Proc.41: 84 (1982).

    Google Scholar 

  18. DePasquale-Jardieu, P.; Fraker, P.J.: The role of corticosterone in the loss of immune function in the zinc-deficient A/J mouse. J. Nutr.109: 1847 (1979).

    CAS  PubMed  Google Scholar 

  19. DePasquale-Jardieu, P.; Fraker, P.J.: Further characterization of the role of corticosterone in the loss of humoral immunity in zinc-deficient A/J mice as determined by adrenalectomy. J. Immun.124: 2650 (1980).

    CAS  PubMed  Google Scholar 

  20. Falchuk, K.H.; Hardy, C.; Ulpino, L.; Vallee, B.: RNA metabolism, manganese, and RNA polymerases of zinc-sufficient and zinc-deficient Euglena gracilis. Proc. natn. Acad. Sci. USA75: 4175 (1978).

    Article  CAS  Google Scholar 

  21. Dardenne, M.; Pleau, J.; Lefrancier, P.; Bach, J.F.: Rôle du zinc et d’autres métaux dans l’activité biologique du FTS (thymuline). C. hebd. Séanc. Acad. Sci., Paris292: 793 (1981).

    CAS  Google Scholar 

  22. Iwata, T.; Incefy, G.S.; Tanaka, T.; Fernandes, G.; Menendez-Botet, C.J.; Pih, K.; Good, R.A.: Circulating thymic hormone levels in zinc deficiency. Cell Immunol.47: 100 (1979).

    Article  CAS  PubMed  Google Scholar 

  23. Chandra, R.K.; Heresi, G.; Au, B.: Serum thymic factor activity in deficiencies of calories, zinc, vitamin A and pyridoxine. Clin. exp. Immunol.42: 332 (1980).

    CAS  PubMed Central  PubMed  Google Scholar 

  24. Chvapil, M.; Stankova, L.; Bernhard, D.; Weldy, P.; Carlson, E.; Campbell, J.: Effect of zinc on peritoneal macrophages in vitro. Infect. Immunity16: 307 (1977).

    Google Scholar 

  25. Ruhl, H.; Kirchner, H.; Bochert, G.: Kinetics of the Zn2+ - stimulation of human peripheral lymphocytes in vitro. Proc. Soc. exp. Biol. Med.137: 1089 (1971).

    Article  CAS  PubMed  Google Scholar 

  26. Berger, N.A.; Skinner, A.M.: Characterization of lymphocyte transformations by zinc ions. J. Cell Biol.61: 45 (1974).

    Article  CAS  PubMed  Google Scholar 

  27. Hart, D.: Effect of zinc chloride on hamster lymphoid cells: mitogenicity and differential enhancement of lipopolysaccharide stimulation of lymphocytes. Infect. Immunity19: 457 (1978).

    CAS  Google Scholar 

  28. Duchateau, J.; Delespesse, G.; Vereeke, P.: Influence of oral zinc supplementation on the lymphocyte response to mitogens of normal subjects. Am. J. clin. Nutr.34: 88 (1981).

    CAS  PubMed  Google Scholar 

  29. Golden, M.H.; Golden, B.E.; Harland, P.S.; Jackson, A.A.: Zinc and immunocompetence in protein-energy malnutrition. Lancetii: 1226 (1978).

    Article  Google Scholar 

  30. Cunningham-Rundles, C.; Cunningham-Rundles, S.; Iwata, T.; Incefy, G.; Garofalo, J.A.; Menendez-Botet, C.; Lewis, V.; Twomey, J.J.; Good, R.A.: Zinc deficiency, depressed thymic hormones and T lymphocyte dysfunction in patients with hypogamma globulinemia. Clin. Immunol. Immunopathol.21: 387 (1981).

    Article  CAS  PubMed  Google Scholar 

  31. Beach, R.S.; Gershwin, M.E.; Hurley, L.S.: Nutritional factors and autoimmunity: immunopathology of zinc deprivation in New Zealand mice. J. Immun.126: 1999 (1981).

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Rights and permissions

Reprints and permissions

About this article

Cite this article

raker, P.J.F. Zinc deficiency: A common immunodeficiency state. Surv. immunol. Res. 2, 155–163 (1983). https://doi.org/10.1007/BF02918575

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02918575

Keywords

Navigation