Proceedings of the Indian Academy of Sciences - Chemical Sciences

, Volume 93, Issue 3, pp 261–269

Structures of isopropylidene nucleoside derivatives: implications for ribose ring flexibility under external cyclic constraints

  • M. A. Viswamitra
  • N. Gautham
Structural Chemistry

DOI: 10.1007/BF02840518

Cite this article as:
Viswamitra, M.A. & Gautham, N. Proc. Indian Acad. Sci. (Chem. Sci.) (1984) 93: 261. doi:10.1007/BF02840518


Crystal structures of six isopropylidene nucleoside derivatives are described. The results show that, under external cyclic constraints, the ribose assumes a variety of unusual conformations. In those compounds which possess a base-to-sugar cyclization through the C(4′) atom, the furanose pucker is predominantly C(4′)-endo, O(4′)-exo. The possible relevance of the sulphur geometry in two of the compounds to certain structural aspects of the action of the enzyme thymidylate synthetase is also pointed out.


Crystal structureisopropylidene nucleoside derivativesribose ring flexibilitysulphur geometryexternal cyclization

Copyright information

© Indian Academy of Sciences 1984

Authors and Affiliations

  • M. A. Viswamitra
    • 1
  • N. Gautham
    • 1
  1. 1.Department of Physics and ICMR Centre on Genetics and Cell BiologyIndian Institute of ScienceBangaloreIndia