Summary
To study the relationship between polymorphism of vitamin D receptor (VDR) allele with formation of calcium oxalate calculus and find the predisposing genes of calcium oxalate calculus, we screened out 150 patients who suffered from calcium oxalate calculus. 36 of them had idiopathic hypercalciuria according to analysis of calculus component and assay of urine calcium. The polymorphisms of VDR gene Taq1, Apa1 and Fok1 were detected using PCR-RFLP technique and the correlation were analyzed between the polymorphism and urinary calculus or between the polymorphism and hypercalciuria. The difference in each genotypic frequency of the allele of promoter Fok1 between calculus group and healthy group or between idiopathic hypercalciuria calculus group and health group was significant. The content of 24-h urine calcium of those who had genotype ff was obviously higher than that of those who have other genotypes in the same group. There was no significant difference in the polymorphism of gene Apa1 and Taq1 between each two groups. It is concluded that hypercalciuria and calcium oxalate calculus were related to the polymorphism of VDR gene’s promoter Fok1 allele, but it had nothing to do with the polymorphism of gene Apa1 and Taq1. The genotype ff was a candidate heredity marker of calcium calculus disease.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
Gsur A, Madersbacher S, Haidinger Get al. Vitamin D receptor gene polymorphism and prostate cancer risk. Prostate, 2002, 51(1): 30
Huang C M, Wu M C, Wu J Yet al. Association of vitamin D receptor gene BsmI polymorphisms in Chinese patients with systemic lupus erythematosus. Lupus 2002, 11(1): 31
Peters U, McGlynn K A, Chatterjee Net al. Vitamin D, calcium, and vitamin D receptor polymorphism in colorectal adenomas. Cancer Epidemiol Biomarkers Prev, 2001, 10(12): 1267
Yokoyama K, Shigematsu T, Kagami Set al. Vitamin D receptor gene polymorphism detected by digestion with Apa I influences the parathyroid response to extracellular calcium in Japanese chronic dialysis patients. Nephron, 2001, 89(3): 315
Kitagawa I, Kitagawa Y, Nagaya Tet al. Interplay of physical activity and vitamin D receptor gene polymorphism on bone mineral density. J Epidemiol, 2001 Sep, 11(5): 229
Wilkinson R J, Llewelyn M, Toossi Zet al. Influence of vitamin D deficiency and vitamin D receptor polymorphisms on tuberculosis among Gujarati Asians in west London: a case-control study. Lancet, 2000, 355 (9204): 618
Curran J E, Vaughan T, Lea R Aet al. Association of A vitamin D receptor polymorphism with sporadic breast cancer development. Int J Cancer, 1999, 83(6): 723
Ames S K, Ellis K J, Gunn S Ket al. Vitamin D receptor gene Fok1 polymorphism predicts calcium absorption and bone mineral density in children. J Bone Miner Res, 1999, 14(5): 740
Heilberg I P, Teixeira S H, Martini L Aet al. Vitamin D receptor gene polymorphism and bone mineral density in hypercalciuric calcium-stone-forming patients. Nephron, 2002, 90(1): 51
Chen W C, Chen H Y, Hsu C Det al. No association of vitamin D receptor gene BsmI polymorphisms with calcium oxalate stone formation. Mol Urol, 2001, 5(1): 7
Ruggiero M, Pacini S, Amato Met al. Association between vitamin D receptor gene polymorphism and nephrolithiasis. Miner Electrolyte Metab, 1999, 25(3): 185
Jackman S V, Kibel A S, Ovuworie C Aet al. Familial calcium stone disease: TaqI polymorphism and the vitamin D receptor. J Endourol, 1999, 13(4): 313
Chen W C, Chen H Y, Lu H Fet al. Association of the vitamin D receptor gene start codon Fok1 polymorphism with calcium oxalate stone disease. BJU Int, 2001, 87 (3): 168
Ingles S A, Wang J, Coetzee G Aet al. Vitamin D receptor polymorphisms and risk of colorectal adenomas (United States). Cancer Causes Control, 2001, 12(7): 607
Lim K S, Kim E K, Choi Y Met al. Association of vitamin D receptor and estrogen receptor gene polymorphisms with bone mass in postmenopausal Korean women. Menopause, 2001, 8(3): 222
Choi Y M, Jun J K, Choe Jet al. Association of the vitamin D receptor start codon polymorphism (Fok1) with bone mineral density in postmenopausal Korean women. J Hum Genet, 2000, 45(5): 280
Chiu K C, Chuang L M, Yoon C. The vitamin D receptor polymorphism in the translation initiation codon is a risk factor for insulin resistance in glucose tolerant Caucasians. BMC Med Genet, 2001, 2(1): 2
Author information
Authors and Affiliations
Additional information
Wang Shaogang, male, born in 1968, M. D., Ph.D.
This project was supported by the National Natural Science Foundation of China (Serial No: 30200283).
Rights and permissions
About this article
Cite this article
Shaogang, W., Jihong, L., Shaoqun, H. et al. Association of vitamin D receptor gene polymorphisms with calcium oxalate calculus disease. Current Medical Science 23, 38–41 (2003). https://doi.org/10.1007/BF02829458
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/BF02829458