Skip to main content
SpringerLink
Log in

Zinc acutely and temporarily inhibits adrenal cortisol secretion in humans

A preliminary report

  • Published:
Biological Trace Element Research Aims and scope Submit manuscript

Abstract

Hypo-and hyperzincemia has been reported to cause alterations in the adrenal secretion. To determine the acute effect of zinc on cortisol levels, we studied 27 normal individuals of both sexes aged 20–27 y after a 12-h fast. The tests were initiated at 7:00am when an antecubital vein was punctured and a device for infusion was installed and maintained with physiological saline. Zinc was administered orally at 8:00am. Subjects were divided into an experimental group of 13 individuals who received doses of 25, 37.5, and 50 mg of zinc and a control group of 14 individual who received 20 mL of physiological saline. Serial blood samples were collected over a period of 240 min after basal samples (−30 and 0 min). We detected an acute inhibitory effect of zinc on cortisol secretion during 240 min of the study period in the experimental group.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Similar content being viewed by others

References

  1. E. J. Underwood,Trace Elements in Human and Animal Nutrition, 4th ed., E. J. Underwood, ed., Academic, NY, 1977, pp. 196–242.

    Google Scholar 

  2. J. Quarterman,Proc. Nutr. Soc. 31, 74-A (1982).

    Google Scholar 

  3. J. Quarterman,Trace Element Metabolism in Animals-2, W. G. Hoekstra, J. W. Suttie, H. E. Ganther, and W. Mertz, eds. University Park Press, Baltimore, 1974, pp. 742–744.

    Google Scholar 

  4. R. I. Henkin,Trace Element Metabolism in Animals-2, W. G. Hoekstra, J. W. Suttie, H. E. Ganther, and W. Mertz, eds., University Park Press, Baltimore, 1974, pp. 647–651.

    Google Scholar 

  5. K. R. Etzel, S. G. Shapiro, and R. J. Cousins,Biochem. Biophys. Res. Commun. 89, 1120 (1979).

    Article  PubMed  CAS  Google Scholar 

  6. M. M. Parker, F. L. Humoller, and D. J. Mahler,Clin. Chem. 13, 40 (1967).

    PubMed  CAS  Google Scholar 

  7. S. Siegel,Nonparametric Statistics for the Behavioral Sciences, 1st ed., S. Siegel, ed., McGraw-Hill, NY, 1956, pp. 61–158.

    Google Scholar 

  8. W. J. Bettger and B. L. O'dell,Life Sci. 28, 1425 (1981).

    Article  PubMed  CAS  Google Scholar 

  9. K. J. Catt and M. L. Dufau,Ann. Rev. Physiol. 39, 529 (1977).

    Article  CAS  Google Scholar 

  10. W. Kazimierczak and C. Maslinski,Agentes and Actions 4, 203 (1974).

    Article  CAS  Google Scholar 

  11. M. Chvapil,Med. Clin. North America 60, 799 (1976).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Internal Medicine, Faculdade de Medicina de Botucatu, Universidade Estadual Paulista, 18610, Botucatu, SP

    J. Brandão-Neto, J. S. Marchini, W. P. Pimenta & M. T. T. Tornero

  2. Department of Internal Medicine, Faculdade de Medicina, Universidade de São Paulo, 05403, São Paulo, SP

    B. B. de Mendonça

  3. Department of Physical Chemistry, Faculdade de Ciências Farmacêuticas de Ribeirão Preto, Universidade de São Paulo, 14.049, Ribeirão Preto, SP, Brazil

    T. Shuhama

Authors
  1. J. Brandão-Neto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. B. B. de Mendonça
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. T. Shuhama
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. J. S. Marchini
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. W. P. Pimenta
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. M. T. T. Tornero
    View author publications

    You can also search for this author in PubMed Google Scholar

Rights and permissions

Reprints and permissions

About this article

Cite this article

Brandão-Neto, J., de Mendonça, B.B., Shuhama, T. et al. Zinc acutely and temporarily inhibits adrenal cortisol secretion in humans. Biol Trace Elem Res 24, 83–89 (1990). https://doi.org/10.1007/BF02789143

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/BF02789143

Index Entries

Search

Navigation