Abstract
In experiments with rats, we have found that at enhanced intake of bromide, bromine does not replace chlorine in the thyroid; it replaces iodine. Under our experimental conditions, more than onethird of the iodine content in the thyroid was replaced by bromine. In the thyroid, bromine probably remained in the form of bromide and, in proportional to its increased concentration, the production of iodinated thyronines decreased, with the sum of the iodine and bromine concentrations being constant at the value of 20.51±1.16 μmol/g dry wt of the thyroid. In contrast to other organs, the biological behavior of bromine in the thyroid is not similar to the biological behavior of chlorine but resembles more that of iodine.
Similar content being viewed by others
References
M. Vobecký and A. Babický, Effect of enhanced bromide intake on the concentration ratio I/Br in the rat thyroid gland.Biol. Trace Elem Res. 43–45 509–516 (1994).
S. Ullberg, L. E. Appelgren, C. Y. Clemedson, Y. Ericsson, B. Ewaldsson, B. Sörbo, and R. Söremark, A comparison of the distribution of some halide ions in the body,Biochem. Pharmacol 13, 407–412 (1964).
A. G. Rauws, Pharmacokinetics of bromide ion—an overview,Fd. Chem. Toxic. 21, 379–382 (1983).
M. J. van Logten, M. Wolthuis, A. G. Rauws, and R. Kroes, Short-term toxicity study on sodium bromide in rats,Toxicology 1, 321–327 (1973).
F. X. R. van Leeuwen, E. M. den Tonkelaar, and M. J. van Logten, Toxicity of sodium bromide in rats: effects on endocrine system and reproduction,Fd. Chem. Toxic. 21, 383–389 (1983).
J. Wolff, Transport of iodide and other anions in the thyroid gland,Physiol. Rev. 44, 45–90 (1964).
W. Buchberger, W. Holler, and K. Winsauer, Effects of sodium bromide on the biosynthesis of thyroid hormones and brominated/iodinated thyronines,J. Trace Elem. Electrolytes Health Dis. 4, 25–30 (1990).
A. Taurog and M. L. Dorris, Peroxidase-catalyzed bromination of tyrosine, thyroglobulin, and bovine serum albumin: comparison of thyroid peroxidase and lactoperoxidase.Arch. Biochem. Biophys. 287, 288–296 (1991).
J. Wolff and I. L. Chaikoff, Plasma inorganic iodide a homeostatic regulator of thyroid function,J. Biol. Chem. 174, 555–564 (1948).
J. G. Loeber, M. A. M. Franken, and F. X. R. van Leeuwen, Effect of sodium bromide on endocrine parameters in the rat as studied by immunocytochemistry and radioimmunoassay,Fd. Chem. Toxic. 21, 391–404 (1983).
M. Vobecký, A. Babický, and J. Lener, Effect of increased bromide intake on iodine excretion in rats,Biol. Trace Elem. Res. (in press).
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Vobecký, M., Babický, A., Lener, J. et al. Interaction of bromine with iodine in the rat thyroid gland at enhanced bromide intake. Biol Trace Elem Res 54, 207–212 (1996). https://doi.org/10.1007/BF02784432
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF02784432