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Infections and malnutrition among poor children

  • Symposium: Nutrition
  • Published:
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Abstract

The interactions between malnutrition and infection are mutually adverse. The results of these interactions are of public health importance in developing countries where malnutrition and infection often co-exist. Recent studies highlight the mechanisms involved in these interactions and indicate the necessity for a comprehensive approach to control malnutrition in poor communities.

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References

  1. Scrimshaw NS. Syergism of malnutrition and infection: Evidence from field studies in Guatemala.J Am Med Assoc 1970;212: 1685–92

    Article  CAS  Google Scholar 

  2. Mata LJ. Malnutrition infection interaction in the tropics.Am J Trop Med Hyg 1975;24: 564–574

    PubMed  CAS  Google Scholar 

  3. Chen LC, Chowdury AKMA, Huffman SL. Anthropometric assessment of energy-protein malnutrition and subsequent risk of mortality among preschool aged children.Am J Clin Nutr 1980;33: 1836–45

    PubMed  CAS  Google Scholar 

  4. Brown KH, Gilman RH, Gaffer A et al. Infections associated with severe protein calorie malnutrition in hospitalized infants and children.Nutr Res 1981;1: 33–46

    Article  Google Scholar 

  5. Martens EJ, Meredith HV. Illness history and physical growth. Correlation in junior primary children followed from fall to spring.Am J Dis Child 1942;64: 618–30

    Google Scholar 

  6. Cahn A, Roche AF. The influence of illness and calcium intake on rate of skeletal maturation in children.Br J Nutr 1961;15: 411–417

    Article  PubMed  CAS  Google Scholar 

  7. Hewett D, Westropp CK, Acheson RM. Effect of childish ailments on skeletal development.Br J Prev Soc Med 1955;9: 179

    Google Scholar 

  8. Martinez F, Weidenslaufer A. Diarrhoeas cronicas del prescolar. Sindrome de mala absorcoin, primera parte, Generalidades y etiopatogenia.Rev Chil Pediatr 1963;34: 1

    CAS  Google Scholar 

  9. Waterlow J, Vergara A.Protein malnutrition in Brazil. Rome, FAO, Nutritional studies 1956; No. 14

    Google Scholar 

  10. Venkatachalam PS, Srikantia SG, Gopalan C. Clinical features of nutritional oedema syndrome in children.Indian J Med Res 1954;42: 555–568

    PubMed  CAS  Google Scholar 

  11. Martolell R, Habitcht JP, Yarbrough C, Lechtig, Klein RE, Western KA. Acute morbidity and physical growth in rural Guatemalan children.Am J Dis Child 1975;129: 1296–301

    Google Scholar 

  12. Rowland MGM, Cole TJ, Whitehead RG. A quantitative study into the role of infection in determining nutritional status in Gambian village children.Br J Nutr 1977;37: 441–450.

    Article  PubMed  CAS  Google Scholar 

  13. Pretorius PJ, Davel JGA, Coetzee JN. Some observations on the development of kwashiorkor. A study of 205 cases.South African Med J 1956;30: 396

    CAS  Google Scholar 

  14. Jayalakshmi VT, Gopalan C. Nutrition and tuberculosis. An epidemiological study.Indian J Med Res 1958;46: 87–92

    PubMed  CAS  Google Scholar 

  15. Morley DC. Measles in Nigeria.Am J Dis Child 1962;103: 230–33

    PubMed  CAS  Google Scholar 

  16. Bhaskaram P, Reddy V, Raj S, Bhatnagar RC. Effect of measles on the nutritional status of preschool children.J Trop Med Hyg 1984;87: 21–26

    PubMed  CAS  Google Scholar 

  17. Salomon JB, Mata LJ, Gordon JE. Malnutrition and the common communicable diseases of childhood in rural Guatemala.Am J Public Health 1968;58: 505–516

    CAS  Google Scholar 

  18. Jelliffe DB. Clinical notes on kwashiorkor in Western Nigeria.Am J Trop Med 1953;56: 104

    CAS  Google Scholar 

  19. Bray B. Nitrogen metabolism in West African children.Br J Nutr 1953;7: 3–13

    Article  PubMed  CAS  Google Scholar 

  20. National Institute of Nutrition. Effect of ascariasis and deworming on the nutritional status of children.Ann Rep 1980; p. 78

  21. Scrimshaw NS, Wilson D, Bressani R. Infection and kwashiorkor.J Trop Pediatr 1960;6: 37–43

    PubMed  CAS  Google Scholar 

  22. Johnston JA. Nutritional studies on adolescent girls and their relation to tuberculosis, Springgield III. Thomas, 1953

    Google Scholar 

  23. Co Tui Fw, Kuo NH, Schmidt L. The protein status in pulmonary tuberculosis.Am J Clin Nutr 1954;2: 252–264

    PubMed  CAS  Google Scholar 

  24. Rao BSN, Gopalan C. Nutrition and tuberculosis II. Studies on nitrogen, calcium and phosphorus metabolism in tuberculosis.Indian J Med Res 1958;46: 93–103

    CAS  Google Scholar 

  25. Venkatachalam PS, Patwardhan VN. The role of Ascaris lumbricoides in the nutrition of the host. Effect of ascariasis on digestion of protein.Trans Roy Soc Trop Med Hyg 1953;47: 169–175

    Article  PubMed  CAS  Google Scholar 

  26. Belfrage S. Plasma protein pattern in course of acute infectious disease.Acta Med Scand 1963;173: (suppl) 395; 1–169

    Google Scholar 

  27. Mansharamani RK. Serum electrophoretic pattern in measles.Indian J Child Health 1961;10: 581–587

    PubMed  CAS  Google Scholar 

  28. Giuliani G. The serum protein electrophoretic picture in measles.Minerva Med 1963;54: 3449

    PubMed  CAS  Google Scholar 

  29. Porkitt EM. Effect of measles on plasma albumin in Ugandan village children.Lancet 1971;2: 68–74

    Article  Google Scholar 

  30. Reddy V, Bhaskaram P, Raghuramulu N, et al. Relationship between measles malnutrition and blindness: a prospective study in children.Am J Clin Nutr 1986;45: Jan

  31. National Institute of Nutrition. Measles and malnutrition.Ann Rep 1985; p 64–70

  32. Coovadia HM, Wesley A, Brain P, Henderson LG, Hallett, AF, Vos GH. Immunoparesis and outcome in measles.Lancet 1977;1: 619–621

    Article  PubMed  CAS  Google Scholar 

  33. Bhaskaram P, Raj S, Reddy V. Effect of measles on cell mediated immunity.Indian J Med Res 1983;77: 83–86

    PubMed  CAS  Google Scholar 

  34. Phillips I, Wharton BA. Acute bacterial infection in kwashiorkor and marasmus.Br Med J 1968;1: 407–409

    Article  PubMed  CAS  Google Scholar 

  35. Smythe PM, Schontan M, Breeton Stiles G, et al. Thymolymphatic deficiency and depresslon of cell mediated immunity in protein calorie malnutrition.Lancet 1971;2: 939–943

    Article  PubMed  CAS  Google Scholar 

  36. Hughes WT, Price RA, Sisko F, et al. Protein calorie malnutrition: A host determinant for pneumocystis carinii infection.Am J Dis Child 1974;128: 44–52

    PubMed  CAS  Google Scholar 

  37. Templeton AC. Generalized herpes simplex in malnourished children.J Clin Pathol 1970;23: 24

    Article  PubMed  CAS  Google Scholar 

  38. Purtilo DT, Connor DH. Fatal infections in protein calorie malnourished children with thymolymphatic atrophy.Arch Dis Child 1975;50: 149–152

    PubMed  CAS  Google Scholar 

  39. Che LC, Huq E, Huffman SL. Prospective study of the risk of diarrhoeal diseases according to the nutritional status of children.Am J Epidemiol 1981;114: 284–292

    Google Scholar 

  40. Reddy V. Relationship between diarrhoea and malnutrition.Indian J Pediatr 1985;52: 463–467

    Article  PubMed  CAS  Google Scholar 

  41. Ghai OP, Jaiswal VN. Relationship of undernutrition to diarrhoea in infants and children.Indian J Med Res 1970;58: 789–795

    PubMed  CAS  Google Scholar 

  42. Bhaskaram P, Madhusudan J, Radhakrishna KV, Reddy V. Immune response in malnourished children with measles.J Trop Ped 1986;32: 123–126

    CAS  Google Scholar 

  43. Balch HH, Spencer MT. Phagocytosis by human leukocytes. II Relation of nutritional deficiency in man to phagocytosis.J Clin Invest 1954;33: 1321–28

    PubMed  CAS  Google Scholar 

  44. Tejada C, Arrgueta V, Sanchez M, Albertazzi C. Phagocytic and alkaline phosphatase activity of leukocytes in kwashiorkor.J Pediatr 1964;64: 753–761

    Article  PubMed  CAS  Google Scholar 

  45. Seth V, Chandra RK. Opsonic activity, phagogocytosis and intracellular bactericidal capacity of polymorphs in undernutrition.Arch Dis Child 1972;47: 282–284

    PubMed  CAS  Google Scholar 

  46. Selvaraj RJ, Bhat KS. Metabolic and bacetricidal activities of leukocytes in protein-calorie malnutrition.Am J Clin Nutr 1972;25: 166–174

    PubMed  CAS  Google Scholar 

  47. Selvaraj RJ, Bhat KS. Phagocytosis and leukocyte enzymes in protein calorie malnutrition.Biochem J 1972;127: 255–259

    PubMed  CAS  Google Scholar 

  48. Shilotri PG. Hydrogen peroxide production by leukocytes in protein-calorie malnutrition.Clin Chim Acta 1976;71: 511–514

    Article  PubMed  CAS  Google Scholar 

  49. Reddy V, Jagadeesan V, Raghuramulu N, Bhaskaram C, Srikantia, SG. Functional significance of growth retardation in malnutrition.Am J Clin Nutr 1976;29: 3–7

    PubMed  CAS  Google Scholar 

  50. Bhaskaram P, Satyanarayana K., Sivaprasad J, Jagadeesan V, Naidu AN, Reddy V. Effect of growth retardation in early life on immunocompetence in later life.Indian J Med Res 1980;72: 519–526

    PubMed  CAS  Google Scholar 

  51. Mohan Ram M, Reddy V, Misra S. Lysozyme activity in plasma and leukocytes in malnourished children.Br J Nutr 1974;32: 313–316

    Article  CAS  Google Scholar 

  52. Najjar SS, Stephan M, Asfour RY. Serum levels of immunoglobulins in marasmic infants.Arch Dis Child 1969;44: 120–123

    PubMed  CAS  Google Scholar 

  53. Rosen EV, Geefhuysen J, Ipp I. Immunoglobulin levels in protein calorie malnutrition.South African Med J 1971;45: 980–82

    CAS  Google Scholar 

  54. Chandra RK, Chandra S, Gupta S. Antibody affinity and immune complexes after immunization with tetanus toxiod in protein-energy malnutrition.Am J Clin Nutr 1984;40: 131–134

    PubMed  CAS  Google Scholar 

  55. Bhaskaram P, Madhusudan J, Radhakrishna KV, Raj S. Immunological response to measles vaccination in poor communities.Hum Nutr Clin Nutr 1986;40c: 295–300

    Google Scholar 

  56. Brown RE, Katz M. Antigenic stimulation in undernourished children.East African Med J 1965;42: 221–232

    CAS  Google Scholar 

  57. Jose DG, Welch JS, Doherty RL. Humoral and cellular immune responses to streptococci, influenza and other antigens in Australian aboriginal school children.Anstralian Pediatr J 1970;6: 192

    Google Scholar 

  58. Reddy V, Raghuramulu N, Bhaskaram C. Secretory IgA in protein-calorie malnutrition.Arch Dis Child 1976;51: 871–874

    PubMed  CAS  Google Scholar 

  59. Chandra RK. Reduced serum and secretory antibody response to live attenuated measles and poliovirus vaccines in malnourished children.Br Med J 1975;28: 583–585

    Google Scholar 

  60. Jagadeesan V, Reddy V. Serum complement levels in malnourished children.Indian J Med Res 1979;70: 745–749

    PubMed  CAS  Google Scholar 

  61. Neuman CG, Lawlor GJ, Stein ER, et al. Immunological responses in malnourished children.Am J Clin Nutr 1975;2: 89–104

    Google Scholar 

  62. Sirisinha S, Suskinod R, Edelman R, Charupatana C, Olson RE. Complement and C3 proactivator levels in children with proteincalorie malnutrition and effect of dietary treatment.Lancet 1973;1: 1016–1020

    Article  PubMed  CAS  Google Scholar 

  63. Vint FN. Postmortem findings in the natives of Kenya.East African Med J 1937;13: 332

    Google Scholar 

  64. Watts T. Thymus weights in malnourished children.J Trop Pediatr 1969;15: 155–158

    PubMed  CAS  Google Scholar 

  65. Bhaskaram C, Reddy V. Cell mediated immunity in proteincalorie malnutrition.J Trop Ped Environ Child Health 1974;20: 284–286

    CAS  Google Scholar 

  66. Chandra RK, Neuberne PM. Immunocompetence in undernutrition: In:Nutrition infection and immunity. Mechanism of interaction. New York: Plenum Press, 1977; p 78

    Google Scholar 

  67. Chandra RK, Gupta S, Singh H. Inducer and suppressor T cell subsets in protein energy malnutrition: Analysis by monoclonal antibodies.Nutr Res 1982;2: 21–26

    Article  Google Scholar 

  68. Bhaskaram P, Reddy V. Macrophage and leukocyte migration inhibition factors in kwashiorkor.Indian J Med Res 1982;75: 679–681

    Google Scholar 

  69. Bhaskaram P, Reddy V. Cutaneous inflammatory response in kwashiorkor.Indian J Med Res 1982;76: 849–853

    PubMed  CAS  Google Scholar 

  70. Bhaskaram P. Macrophage function in severe protein energy malnutrition.Indian J Med Res 1980;71: 247–250

    PubMed  CAS  Google Scholar 

  71. Bhaskaram P, Reddy V. Macrophage functions in kwashiorkor.Indian J Pediatr 1982;49: 497–499

    PubMed  CAS  Google Scholar 

  72. Bhaskaram P, Sivakumar B. Interleukin-1 in malnutrition.Arch Dis Child 1986;61: 182–185

    PubMed  CAS  Google Scholar 

  73. Jose DG, Stutman O, Good RA. Long term effects on immune function of early nutritional deprivation.Nature 1973;241: 57–58

    Article  PubMed  CAS  Google Scholar 

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  1. National Institute of Nutrition, Indian Council of Medical Research, Jamai Osmania P.O., 50007, Hyderabad, A.P.

    P. Bhaskaram

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Bhaskaram, P. Infections and malnutrition among poor children. Indian J Pediatr 54, 535–545 (1987). https://doi.org/10.1007/BF02749048

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