Molecular Neurobiology

, Volume 20, Issue 1, pp 29–44

Signaling of neuronal cell death by the p75NTR neurotrophin receptor

Authors

  • Elizabeth J. Coulson
    • Development and Neurobiology Group, The Walter and Eliza Hall Institute of Medical ResearchPO The Royal Melbourne Hospital
  • Kate Reid
    • Development and Neurobiology Group, The Walter and Eliza Hall Institute of Medical ResearchPO The Royal Melbourne Hospital
  • Perry F. Bartlett
    • Development and Neurobiology Group, The Walter and Eliza Hall Institute of Medical ResearchPO The Royal Melbourne Hospital
Article

DOI: 10.1007/BF02741363

Cite this article as:
Coulson, E.J., Reid, K. & Bartlett, P.F. Mol Neurobiol (1999) 20: 29. doi:10.1007/BF02741363

Abstract

The neurotrophin receptor (p75NTR) is best known for mediating tropic support by participating in the formation of high-affinity nerve growth factor (NGF) receptor complexes withtrkA, however, p75NTR more recently has been shown to act as a bona fide death-signaling receptor, which can signal independently oftrkA. This article discusses the evidence for an active role of p75NTR in neuronal cell death and the mechanisms controlling this process, including roles for Bcl-2 family members, the c-jun stress kinase JNK, the transcription factor nuclear factor kappa B (NFκB), and caspases.

Index Entries

p75NTR apoptosis cell death signaling Bc1-2 family nerve growth factor neurotrophin neuronal survival knockout caspase

Copyright information

© Humana Press Inc 1999