, Volume 20, Issue 1, pp 29-44

Signaling of neuronal cell death by the p75NTR neurotrophin receptor

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Abstract

The neurotrophin receptor (p75NTR) is best known for mediating tropic support by participating in the formation of high-affinity nerve growth factor (NGF) receptor complexes withtrkA, however, p75NTR more recently has been shown to act as a bona fide death-signaling receptor, which can signal independently oftrkA. This article discusses the evidence for an active role of p75NTR in neuronal cell death and the mechanisms controlling this process, including roles for Bcl-2 family members, the c-jun stress kinase JNK, the transcription factor nuclear factor kappa B (NFκB), and caspases.