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Molecular cloning and functional expression of a serotonin receptor fromCaenorhabditis elegans

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Abstract

A cDNA encoding a serotonin receptor has been isolated from aCaenorhabditis elegans mixed stage cDNA library. The nematode serotonin receptor, designated 5HT-Ce, was permanently expressed in murine Ltk-cells, where it mediates adenylate cyclase attenuation. Sequence analysis and the pharmacological profiles demonstrate its relatedness not only toDrosophila andLymnae 5HT receptors but also to mammalian 5HT1a receptors. The 5HT-Ce gene does not map close to the position of any known serotonergic mutations.

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Olde, B., McCombie, W.R. Molecular cloning and functional expression of a serotonin receptor fromCaenorhabditis elegans . J Mol Neurosci 8, 53–62 (1997). https://doi.org/10.1007/BF02736863

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